Intricate Transcriptional Networks of Classical Brown and Beige Fat Cells

Frontiers in Endocrinology
Jun Hong ParkSean Bong Lee

Abstract

Brown adipocytes are a specialized cell type that is critical for adaptive thermogenesis, energy homeostasis, and metabolism. In response to cold, both classical brown fat and the newly identified "beige" or "brite" cells are activated by β-adrenergic signaling and catabolize stored lipids and carbohydrates to produce heat via UCP1. Once thought to be non-existent in adults, recent studies have discovered active classical brown and beige fat cells in humans, thus reinvigorating interest in brown and beige adipocytes. This review will focus on the newly discovered transcription factors and microRNAs that specify and orchestrate the classical brown and beige fat cell development.

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May 24, 2016·Cardiology Research and Practice·Juan SalazarValmore Bermúdez
Sep 14, 2017·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·K VerbovenE E Blaak
Apr 18, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Kenichi Matsushita, Victor J Dzau
Dec 10, 2016·The Journal of Endocrinology·Liping Luo, Meilian Liu
Dec 11, 2020·Cells·Yun Kyung LeeJun Hong Park

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Methods Mentioned

BETA
ChIP-seq

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