Intrinsic activity temporal structure reactivity to behavioural state change is correlated with depressive symptoms.

The European Journal of Neuroscience
Niall W DuncanTimothy J Lane

Abstract

The brain's intrinsic activity plays a fundamental role in its function. In normal conditions this activity is responsive to behavioural context, changing as an individual switches between directed tasks and task-free conditions. A key feature of such changes is the movement of the brain between corresponding critical and sub-critical states, with these dynamics supporting efficient cognitive processing. Breakdowns in processing efficiency can occur, however, in brain disorders such as depression. It was therefore hypothesised that depressive symptoms would be related to reduced intrinsic activity responsiveness to changes in behavioural state. This was tested in a mixed group of major depressive disorder patients (n = 26) and healthy participants (n = 37) by measuring intrinsic EEG activity temporal structure, quantified with detrended fluctuation analysis (DFA), in eyes-closed (EC) and eyes-open task-free states and contrasting between the conditions. The degree to which DFA values changed between the states was found to correlate negatively with depressive symptoms. DFA values did not differ between states in those with higher symptom levels, meaning that the brain remained in a less flexible sub-critical condition. This sub...Continue Reading

References

Dec 1, 1996·Journal of Personality Assessment·A T BeckW Ranieri
Jul 26, 2003·NeuroImage·Esther MarxThomas Brandt
Feb 9, 2005·Psychological Medicine·C Donaldson, D Lam
Nov 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Klaus Linkenkaer-HansenSeppo Kähkönen
Feb 6, 2007·Trends in Neurosciences·Dietmar Plenz, Tara C Thiagarajan
Sep 25, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jun-Seok LeeSae-Byul Kim
Oct 4, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Robert J BarryJacqueline A Rushby
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Teresa MontezKlaus Linkenkaer-Hansen
Apr 30, 2009·BMC Neuroscience·Viola PriesemannMichael Wibral
Jul 7, 2009·Behaviour Research and Therapy·Katherine SurrenceShirley Chan
Nov 11, 2009·Journal of Abnormal Psychology·Silke HuffzigerChristine Kuehner
Jul 3, 2010·The American Journal of Psychiatry·Thomas InselPhilip Wang
Aug 24, 2010·Biological Psychiatry·Meng-Chuan LaiJohn Suckling
Dec 15, 2010·PloS One·Tiago L RibeiroSidarta Ribeiro
Jan 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Woodrow L ShewDietmar Plenz
Oct 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Biyu J He
Mar 9, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gustavo Deco, Viktor K Jirsa
Sep 12, 2012·Journal of Psychiatry & Neuroscience : JPN·Niall W Duncan, Georg Northoff
Sep 19, 2012·The European Journal of Neuroscience·F U HohlefeldV V Nikulin
Dec 12, 2012·Frontiers in Physiology·Richard HardstoneKlaus Linkenkaer-Hansen
Feb 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·J Matias PalvaSatu Palva
Apr 19, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Oren ShrikiDietmar Plenz
Oct 15, 2013·Frontiers in Human Neuroscience·Ayna Baladi NejadCédric Lemogne
Jan 17, 2014·Frontiers in Neuroscience·Alexandre GramfortMatti Hämäläinen
May 3, 2014·Trends in Cognitive Sciences·Biyu J He
Feb 2, 2015·Cerebral Cortex·Frederic M StollEmmanuel Procyk
Apr 1, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Marcus E Raichle
Jun 18, 2015·Nature Reviews. Neuroscience·Gustavo DecoMorten L Kringelbach
Dec 2, 2015·PLoS Computational Biology·Shree Hari GautamWoodrow L Shew
Jan 23, 2016·Social Cognitive and Affective Neuroscience·Pengmin QinGeorg Northoff
May 26, 2017·PLoS Computational Biology·Gerald HahnYves Frégnac

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.