Intrinsic Alertness Is Impaired in Patients with Nigrostriatal Degeneration: A Prospective Study with Reference to [123I]FP-CIT SPECT and [18F]FDG PET.

Journal of Alzheimer's Disease : JAD
Lars FringsSabine Hellwig

Abstract

Variations in alertness and attention are common in Lewy body diseases (LBD) and among the core features of dementia with Lewy bodies (DLB). Dopamine transporter SPECT is an accurate biomarker of nigrostriatal degeneration (NSD) in LBD. The present study investigated performance on a computerized alertness test as a potential measure of attention in patients with NSD compared to patients without NSD. Thirty-six patients with cognitive impairment plus at least one core feature of DLB referred for [123I]FP-CIT SPECT imaging were prospectively recruited. Performance in a computerized test of intrinsic alertness was compared between patients with and those without NSD as assessed by [123I]FP-CIT SPECT. Reaction times to auditory stimuli (adjusted for age, sex, and education) were significantly longer in patients with NSD compared to those with a normal [123I]FP-CIT SPECT scan (p < 0.05). Statistical analyses revealed no significant differences comparing reaction times to visual stimuli or dispersion of reaction times between groups. Exploratory analysis in a subgroup of patients with available [18F]FDG PET revealed that longer reaction times were associated with decreased glucose metabolism in the prefrontal cortex (statistical par...Continue Reading

References

Jun 1, 1975·Brain : a Journal of Neurology·D Howes, F Boller
Sep 19, 1992·BMJ : British Medical Journal·I McKeithE Perry
Oct 21, 2000·The British Journal of Psychiatry : the Journal of Mental Science·M P WalkerC G Ballard
Oct 25, 2000·Dementia and Geriatric Cognitive Disorders·M P WalkerC G Ballard
Dec 11, 2002·Neurology·C G BallardM Tovee
Jan 17, 2004·Neuropsychologia·Walter SturmKlaus Willmes
Feb 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·J BradshawA Brodtmann
Oct 21, 2005·Neurology·I G McKeithUNKNOWN Consortium on DLB
Jun 9, 2006·Nature Reviews. Neuroscience·Amir Raz, Jason Buhle
Mar 14, 2007·Neurology·C F LippaUNKNOWN DLB/PDD Working Group
Oct 16, 2007·Neuro-degenerative Diseases·Kurt A JellingerKlaus Seppi
Oct 2, 2009·Journal of Neurology·Peter T NelsonWilliam R Markesbery
Apr 15, 2010·Dementia and Geriatric Cognitive Disorders·Arvid RongveDag Aarsland
Jan 27, 2012·International Journal of Geriatric Psychiatry·David R LeeAlan J Thomas
Oct 24, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Donald L BliwiseLynn Marie Trotti
Jun 21, 2014·Current Opinion in Neurology·Philipp T Meyer, Sabine Hellwig
Aug 19, 2015·Brain : a Journal of Neurology·Lars FringsPhilipp T Meyer
Apr 14, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·L BonanniM Onofrj

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Citations

Jan 17, 2021·Brain and Behavior·Aida ArroyoJuan Pablo Romero

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