Intrinsic and circuit properties favor coincidence detection for decoding oscillatory input

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Javier Perez-OriveGilles Laurent

Abstract

In the insect olfactory system the antennal lobe generates oscillatory synchronization of its output as a framework for coincidence detection by its target, the mushroom body (MB). The intrinsic neurons of the MB (Kenyon cells, KCs) are thus a good model system in which to investigate the functional relevance of oscillations and neural synchronization. We combine electrophysiological and modeling approaches to examine how intrinsic and circuit properties might contribute to the preference of KCs for coincident input and how their decoding of olfactory information is affected by the absence of oscillatory synchronization in their input. We show that voltage-dependent subthreshold properties of KCs bring about a supralinear summation of their inputs, favoring responses to coincident EPSPs. Abolishing oscillatory synchronization weakens the preference of KCs for coincident input and causes a large reduction in their odor specificity. Finally, we find that a decoding strategy that is based on coincidence detection enhances both noise tolerance and input discriminability by KCs.

Citations

Oct 28, 2005·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Anthony Leonardo
Apr 24, 2013·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Wolfgang Rössler, Martin F Brill
Sep 5, 2013·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Joshua P MartinJohn G Hildebrand
Jun 24, 2009·Journal of Computational Neuroscience·Mainak PatelDavid Cai
Oct 22, 2013·Nature Neuroscience·Eyal Gruntman, Glenn C Turner
Jul 5, 2005·Nature Neuroscience·Hiroshi IshikaneMasao Tachibana
Jul 31, 2007·Nature Neuroscience·Collins AssisiMaxim Bazhenov
Apr 30, 2005·Nature Reviews. Neuroscience·Kenneth D Harris
Apr 25, 2007·Nature Reviews. Neuroscience·Alex C Keene, Scott Waddell
Aug 10, 2007·Learning & Memory·Wilder DoucetteDiego Restrepo
Aug 24, 2007·Clinical and Experimental Pharmacology & Physiology·Johannes J LetzkusGreg J Stuart
Apr 19, 2008·PLoS Computational Biology·Luca A FinelliTerrence J Sejnowski
Oct 31, 2009·PLoS Computational Biology·François O DavidNathalie Buonviso
Oct 25, 2012·PLoS Computational Biology·J Vincent ToupsPaul H Tiesinga
Aug 29, 2012·PLoS Computational Biology·Aaditya V Rangan
Oct 25, 2011·PloS One·Florian Blättler, Richard H R Hahnloser
Jun 21, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert A A CampbellGlenn C Turner
Jun 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nitin Gupta, Mark Stopfer
Jun 20, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Angelique C PaulkWulfila Gronenberg
Mar 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maxim BazhenovBrian H Smith
Feb 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joby JosephMark Stopfer
Dec 24, 2013·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Anja FroeseRandolf Menzel
Dec 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ehud Sivan, Nancy Kopell
Aug 6, 2014·Journal of Physiology, Paris·Randolf Menzel
Mar 26, 2013·Journal of Theoretical Biology·Badal Joshi, Mainak Patel
Sep 18, 2012·Neuroscience Letters·Masashi TabuchiKei Nakatani
Oct 4, 2011·Progress in Neurobiology·Joshua P MartinJohn G Hildebrand
Mar 5, 2011·Arthropod Structure & Development·Sarah M Farris
Jul 19, 2008·Arthropod Structure & Development·Angelique C Paulk, Wulfila Gronenberg
Jan 2, 2007·Molecular and Cellular Neurosciences·Summer F AcevedoEfthimios M C Skoulakis
Dec 13, 2006·Trends in Neurosciences·Leslie M Kay, S Murray Sherman
Jan 27, 2015·Current Opinion in Insect Science·Mark Stopfer
Aug 17, 2005·The European Journal of Neuroscience·Mikael A CarlssonBill S Hansson
Jun 8, 2006·Seminars in Cell & Developmental Biology·Pierre-Marie Lledo, Samuel Lagier
Jun 13, 2006·Seminars in Cell & Developmental Biology·Leslie M Kay, Mark Stopfer
Nov 12, 2013·Neuron·Kai ShenGilles Laurent
Aug 19, 2015·Frontiers in Physiology·Martin F BrillWolfgang Rössler
Sep 6, 2011·Current Opinion in Genetics & Development·Sarah G Leinwand, Sreekanth H Chalasani
Aug 16, 2006·Neuron·Bede M BroomeGilles Laurent

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Ron A JortnerGilles Laurent
Journal of Neurophysiology
Glenn C TurnerGilles Laurent
© 2022 Meta ULC. All rights reserved