PMID: 7431295Jul 1, 1980Paper

Intrinsic and extrinsic factors affecting the viability of Mus caroli x M. musculus hybrid embryos

Journal of Reproduction and Fertility
W I FrelsV M Chapman


Interspecific hybrids between M. musculus and M. caroli, a wild species of mouse, were produced by artificial insemination, although the species do not normally interbreed. However, the success rate was low, with many embryos dying at various stages of pregnancy. Hybrid embryos were retarded in comparison with either parent species from the earliest stages of development, suggesting that intrinsic problems of genomic incompatibility play a major role in poor hybrid survival. However, failure of normal embryo-uterine interactions may also be important, since M. caroli x M. caroli embryos transferred to the M. musculus uterus also failed to survive to term. It is suggested that a maternal immune response to antigens on the foreign trophoblast may be involved.


May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P G Kratzer, V M Chapman
Mar 14, 2002·Molecular Reproduction and Development·Michele CorzettRod Balhorn
Nov 1, 1983·The Journal of Experimental Zoology·J RossantV M Chapman
Sep 13, 2019·Biology of Reproduction·Marcin SzpilaAndrzej K Tarkowski
Dec 17, 1985·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R L Gardner
Nov 26, 2011·Biology of Reproduction·Judith D BrownRachel J O'Neill

Related Concepts

Blastocyst Transfer
Fetal Viability
Hybridization, Intraspecies
Xenograft Procedure
Prenidation Embryo Development, Animal

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.