Intrinsic and extrinsic mechanisms of oocyte loss

Molecular Human Reproduction
Travis C ThomsonJoshua Johnson

Abstract

A great deal of evolutionary conservation has been found in the control of oocyte development, from invertebrates to women. However, little is known of mechanisms that control oocyte loss over time. Oocyte loss is often assumed to be a result of oocyte-intrinsic deficiencies or damage. In fruit flies, starvation results in halted oocyte production by germline stem cells and induces oocyte loss midway through development. When we fed wild-type flies the bacterial compound Rapamycin (RAP) to mimic starvation, production of new oocytes continued, but mid-stage loss sterilized the animals. Surprisingly, follicle cell invasion and phagocytosis of the oocyte preceded any signs of germ cell death. RAP-induced egg chamber loss was prevented when RAP receptor FKBP12 was knocked down specifically in follicle cells. Oogenesis continued past the mid-stages, and these mutants continued to lay embryos that could develop into normal adults. Hence, intact healthy oocytes can be destroyed by somatic cells responding to extrinsic stimuli. We termed this process inducible somatic oocyte destruction. RAP treatment of mouse follicles in vitro resulted in phagocytic uptake of the oocyte by granulosa cells as seen in flies. We hypothesize that extrin...Continue Reading

References

Sep 1, 1979·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·T Steiner, F E Würgler
Jul 12, 1991·Cell·D St JohnstonC Nüsslein-Volhard
Jun 28, 1996·Cell·W EdelmannR Kucherlapati
Jun 1, 1997·Current Opinion in Obstetrics & Gynecology·G S Conway
Mar 21, 1998·Current Biology : CB·M Van DorenR Lehmann
Feb 18, 1999·Development Genes and Evolution·S Y HwangB B Knowles
Jun 17, 1999·Trends in Cell Biology·M E PeplingA C Spradling
Oct 27, 1999·Genomics·P J Romanienko, R D Camerini-Otero
Jan 15, 2000·Science·F Le NaourC Boucheix
Jul 26, 2000·The Journal of Cell Biology·J J SekelskyK C Burtis
Oct 24, 2000·European Journal of Cell Biology·I P NezisL H Margaritis
Oct 25, 2000·Molecular Human Reproduction·P T SaundersM Bownes
Nov 4, 2000·Biology of Reproduction·P J DevineP B Hoyer
Nov 9, 2000·Genes & Development·H ZhangT P Neufeld
Feb 22, 2001·Developmental Biology·D Drummond-Barbosa, A C Spradling
Feb 24, 2001·Toxicologic Pathology·P B HoyerI G Sipes
Apr 12, 2001·Genes & Development·A C GingrasN Sonenberg
Jun 9, 2001·Developmental Biology·M E Pepling, A C Spradling
Sep 22, 2001·Cell Structure and Function·T NoceN Tsunekawa
Jan 24, 2002·Biology of Reproduction·Leisa J Morrison, Jennifer L Marcinkiewicz
Apr 20, 2002·Zygote : the Biology of Gametes and Early Embryos·Maowu GuoTsuneatsu Mori
Apr 20, 2002·Zygote : the Biology of Gametes and Early Embryos·Ken Sahara, Naoko Kawamura
Aug 3, 2002·Genes & Development·Jason R KennerdellRichard W Carthew
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Charles D LoftinRobert Langenbach
Jan 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Frederick L MooreRenee A Reijo Pera
Apr 5, 2003·Current Biology : CB·Patricia A HuntTerry J Hassold
Apr 25, 2003·Gene Expression Patterns : GEP·Joachim MarholdBernard M Mechler
Aug 30, 2003·Science·Masayuki TsudaYumiko Saga
Oct 22, 1963·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·T G BAKER
Sep 23, 2003·Nature Cell Biology·Ryan S UdanGeorg Halder

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Citations

Aug 24, 2013·Trends in Cell Biology·Victoria K JenkinsKimberly McCall
Oct 30, 2012·Human Reproduction Update·S M NelsonR A Anderson
Feb 7, 2016·Developmental Biology·Kenneth BörnerPeter B Becker
Dec 17, 2011·Genesis : the Journal of Genetics and Development·Travis C ThomsonJoshua Johnson
Jan 24, 2012·Developmental Cell·Cristina Pallares-CartesAurelio A Teleman
Nov 27, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Aziz Ur Rehman AzizBo Liu
Jun 17, 2020·Reproductive Sciences·Clyde J WrightJoshua Johnson
Apr 16, 2021·Frontiers in Cell and Developmental Biology·Xiaoli LiuHongyan Xu
Apr 21, 2021·Reproductive Toxicology·Uma Priya MohanSankarganesh Arunachalam

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