Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation

International Journal of Cosmetic Science
C SerreJ-M Botto

Abstract

In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular signals are transduced via dedicated signalling pathways and mostly converge to MITF, a transcription factor integrating upstream signalling and regulating downstream genes involved in the various inherent mechanisms modulating melanogenesis. The synthesis of melanin pigments occurs in melanocytes inside melanosomes where melanogenic enzymes (tyrosinase and related proteins) are addressed with the help of specific protein complexes. The melanosomes loaded with melanin are then transferred to keratinocytes. A more elaborate level of melanogenesis regulation comes into play via the action of non-coding RNAs (microRNAs, lncRNAs). Besides this canonical regulation, melanogenesis can also be modulated by other non-specific intrinsic pathways (hormonal environment, inflammation) and by extrinsic factors (solar irradiation such as ultraviolet irradiation, environmental pollution). We developed a bioinformatic interaction network gathering the multiple aspects of melanogenesis and skin pigmentation as a resource to better understand and study skin pigmentation biology.

References

Nov 30, 1992·Biochemical and Biophysical Research Communications·K U SchallreuterA J Thody
Nov 1, 1991·The Journal of Cell Biology·M YaarB A Gilchrest
Apr 15, 1991·Biochemical and Biophysical Research Communications·K MatsumotoT Nakamura
Sep 1, 1987·The Journal of Investigative Dermatology·Y TomitaH Tagami
Sep 1, 1995·The Journal of Endocrinology·S D McLeodR S Mason
Jan 1, 1993·The Journal of Investigative Dermatology·J J YohnM R Zamora
Feb 1, 1996·Experimental Dermatology·K U SchallreuterM L Gardner
Sep 1, 1996·Archives of Dermatological Research·N PuriW Westerhof
Feb 26, 2000·The Journal of Investigative Dermatology·M HaraB A Gilchrest
Apr 5, 2000·The Journal of Biological Chemistry·K TakedaS Shibahara
Apr 20, 2000·The Journal of Investigative Dermatology·H R ByersB A Gilchrest
May 8, 2000·Journal of Cellular Physiology·C FratiF Nicoletti
Oct 12, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·J E WikbergA Skottner
Nov 25, 2000·Human Molecular Genetics·B IncertiA Ballabio
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·T KushimotoV J Hearing
Sep 11, 2001·Pigment Cell Research·M Seiberg
Jun 6, 2003·The Journal of Investigative Dermatology·Söbia KauserDesmond J Tobin
Jun 24, 2003·The American Journal of Pathology·Jinyan DuDavid E Fisher
Jul 16, 2003·Molecular and Cellular Biology·Taruho S KurodaMitsunori Fukuda
Aug 20, 2003·The Journal of Investigative Dermatology·Glynis ScottRujiing Han
Jun 12, 2004·The Journal of Investigative Dermatology·Söbia KauserDesmond J Tobin
Sep 24, 2004·Physiological Reviews·Andrzej SlominskiJacobo Wortsman
Nov 5, 2004·Cellular and Molecular Life Sciences : CMLS·L Rönnstrand
Dec 1, 2004·Annual Review of Genetics·Eiríkur SteingrímssonNancy A Jenkins
Dec 2, 2004·American Journal of Physiology. Endocrinology and Metabolism·Andrzej SlominskiJacobo Wortsman
Feb 8, 2005·The Journal of Biological Chemistry·Toshihiko HoashiVincent J Hearing
Apr 19, 2005·Journal of Neuroimmunology·Andrzej SlominskiJacobo Wortsman
May 17, 2005·Pigment Cell Research·Karen Joyce DunnWilliam J Pavan
Jun 11, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Natsuho ItoRalf Paus
Oct 26, 2005·Journal of Cellular Physiology·A SlominskiJ Wortsman

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Citations

May 23, 2019·Journal of Cosmetic Dermatology·Kiranjeet KaurIndu Bala
Sep 22, 2019·Journal of Burn Care & Research : Official Publication of the American Burn Association·Bonnie C CarneyDean S Rosenthal
Sep 29, 2019·Pigment Cell & Melanoma Research·Christopher R ArnetteKathleen J Green
Feb 11, 2020·Cell Structure and Function·Soujiro Marubashi, Mitsunori Fukuda
Mar 1, 2019·International Journal of Molecular Sciences·Jung-Im NaKyung-Chan Park
May 1, 2019·International Journal of Molecular Sciences·Nurinanda Prisky QomaladewiJae Youl Cho
Jun 13, 2020·Frontiers in Veterinary Science·María Evarista Arellano-GarcíaOlivia Torres-Bugarín
Aug 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dae Kil JangHee Min Yoo
Dec 29, 2020·Journal of Cosmetic Dermatology·Jing WangAnquan Yang
Dec 23, 2020·The Journal of Investigative Dermatology·Eleni FitsiouMarco Demaria
Dec 23, 2020·International Journal of Molecular Sciences·Yong-Pyo ChoiYoungsoo Kim
Sep 18, 2020·Autoimmunity Reviews·Pui Mun WongHuimin Zhang
Apr 2, 2021·Clinical, Cosmetic and Investigational Dermatology·Maria Grazia FerraroEttore Novellino
May 14, 2021·Ageing Research Reviews·Shihang ZhouQinghai Zeng
Jun 9, 2021·Lasers in Medical Science·G LodiS P Nisticò
May 29, 2021·Pigment Cell & Melanoma Research·Hee Young KangMauro Picardo
Jul 3, 2021·International Journal of Molecular Sciences·Yekatsiaryna HushchaMonica De Mattei
Jul 26, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Mohd Farhan Siddiqui, Moon-Moo Kim
Jul 28, 2021·International Journal of Cosmetic Science·Juanjuan ChenJie Qiu
Aug 7, 2019·Seminars in Cancer Biology·Joshua L Hood
Nov 4, 2021·Journal of the Academy of Nutrition and Dietetics·Vivien W FamRobert M Hackman
Dec 1, 2021·Molecular Ecology·Sarah H D SantosDavid W Coltman

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