Intrinsic carbapenem-hydrolyzing oxacillinases from members of the genus Pandoraea

Antimicrobial Agents and Chemotherapy
Ines Schneider, Adolf Bauernfeind

Abstract

We analyzed the oxacillinases of isolates of six different species of Pandoraea, a genus that colonizes the respiratory tract of cystic fibrosis patients. The isolates produced carbapenem-hydrolyzing enzymes causing elevated MICs for amoxicillin, piperacillin, meropenem, and imipenem when expressed in an Escherichia coli host strain. Sequencing revealed nine new oxacillinases (OXA-151 to OXA-159) with a high degree of identity among isolates of the same species; however, they had much lower interspecies similarities. The intrinsic oxacillinase genes might therefore be helpful for correct identification of Pandoraea isolates.

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Citations

Jun 1, 2016·Frontiers in Microbiology·Mark AmbroseLouise F Roddam
Aug 11, 2018·Current Opinion in Pulmonary Medicine·Heather Green, Andrew M Jones
Nov 26, 2019·Future Microbiology·Jumamurat R BayjanovAd C Fluit
Jan 1, 2021·The Journal of Antimicrobial Chemotherapy·Eun-Jeong Yoon, Seok Hoon Jeong
Apr 16, 2021·Infection and Drug Resistance·Elias BodendoerferBarbara Hasse

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