Intrinsic cardiac adrenergic (ICA) cell density and MAO-A activity in failing rat hearts

Journal of Muscle Research and Cell Motility
Vincent W W van EifWillem J van der Laarse

Abstract

The efficiency (work/oxygen consumption) of isolated papillary muscles from failing hearts is reduced. We investigated whether this can be due to an increase of intrinsic cardiac adrenergic (ICA) cell density. The number of ICA cells in the septum and both ventricular walls was determined by tyrosine hydroxylase immunohistochemistry in rats with monocrotaline-induced pulmonary hypertension. We found that the number of ICA cells is about 200,000 per rat heart. ICA cell density was significantly lower in right ventricular myocardium of hypertrophied hearts (P < 0.01). MAO-A enzyme histochemistry and inhibition experiments with clorgyline in papillary muscles were performed to localize the enzyme and to determine its oxygen consumption. Upregulation of MAO-A was found in the right ventricular wall and papillary muscles of failing hearts (P = 0.018). A positive correlation between ICA cell density and MAO-A activity was absent. Clorgyline (2 μM) decreased the basal rate of oxygen consumption of right ventricular papillary muscles by 65 μM O(2)/s (P = 0.027). This rate can only be maintained for several seconds judging from the catecholamine content of the preparations reported previously. High ICA cell activity rather than density ...Continue Reading

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Citations

Mar 19, 2014·Journal of Muscle Research and Cell Motility·Coen A C OttenheijmJolanda van der Velden
Aug 31, 2016·Pflügers Archiv : European journal of physiology·E L PetersR T Jaspers
Aug 19, 2020·Open Biology·Alexander Grassam-RoweMing Lei
Sep 29, 2017·Cardiovascular Research·Berend E WesterhofAnton Vonk Noordegraaf
Aug 31, 2018·Histochemistry and Cell Biology·Eva L PetersWillem J van der Laarse
Jul 26, 2018·Journal of Neural Transmission·Jeanne Mialet-PerezAngelo Parini
Dec 3, 2020·American Journal of Respiratory Cell and Molecular Biology·Xiao-Qing SunHarm Jan Bogaard
Sep 25, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Kevin HoweDavid J Crossman

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