Intrinsic connectivity network dynamics in PTSD during amygdala downregulation using real-time fMRI neurofeedback: A preliminary analysis.

Human Brain Mapping
Andrew A NicholsonRuth A Lanius

Abstract

Posttraumatic stress disorder (PTSD) has been associated with a disturbance in neural intrinsic connectivity networks (ICN), including the central executive network (CEN), default mode network (DMN), and salience network (SN). Here, we conducted a preliminary investigation examining potential changes in ICN recruitment as a function of real-time fMRI neurofeedback (rt-fMRI-NFB) during symptom provocation where we targeted the downregulation of neural response within the amygdala-a key region-of-interest in PTSD neuropathophysiology. Patients with PTSD (n = 14) completed three sessions of rt-fMRI-NFB with the following conditions: (a) regulate: decrease activation in the amygdala while processing personalized trauma words; (b) view: process trauma words while not attempting to regulate the amygdala; and (c) neutral: process neutral words. We found that recruitment of the left CEN increased over neurofeedback runs during the regulate condition, a finding supported by increased dlPFC activation during the regulate as compared to the view condition. In contrast, DMN task-negative recruitment was stable during neurofeedback runs, albeit was the highest during view conditions and increased (normalized) during rest periods. Critically...Continue Reading

Associated Clinical Trials

References

Jul 1, 1997·Comprehensive Psychiatry·C Zlotnick, T Pearlstein
Apr 3, 2001·Annual Review of Neuroscience·E K Miller, J D Cohen
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Mar 5, 2003·Child Abuse & Neglect·David P BernsteinWilliam Zule
Jun 7, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael Petrides
Nov 11, 2005·Journal of Traumatic Stress·John BriereMarsha Runtz
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William W SeeleyMichael D Greicius
May 4, 2007·Trends in Cognitive Sciences·Etienne Koechlin, Christopher Summerfield
Jun 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Nico U F DosenbachSteven E Petersen
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Devarajan SridharanVinod Menon
Jan 14, 2009·Neuroinformatics·Jan Gläscher
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christophe HabasMichael D Greicius
Jul 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Stephen M SmithChristian F Beckmann
Jul 25, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lisa M Shin, Israel Liberzon
Dec 2, 2009·Journal of Fluency Disorders·Ross G MenziesSue O'Brian
Apr 3, 2010·The American Journal of Psychiatry·Ruth A LaniusDavid Spiegel
Jun 1, 2010·Brain Structure & Function·Vinod Menon, Lucina Q Uddin
Jun 24, 2010·Journal of Psychiatry & Neuroscience : JPN·Judith K DanielsRuth A Lanius
Feb 26, 2011·Neuropharmacology·Robin L AupperleMartin P Paulus
May 26, 2011·NeuroImage·Pengmin Qin, Georg Northoff
Jun 16, 2011·Journal of Cognitive Neuroscience·Angela R LairdPeter T Fox
Sep 13, 2011·Trends in Cognitive Sciences·Vinod Menon
Nov 22, 2011·Frontiers in Psychiatry·Christine A RabinakK Luan Phan
Dec 27, 2011·NeuroImage·Clas LinnmanDavid Borsook
Feb 9, 2012·Journal of Psychiatry & Neuroscience : JPN·Rebecca K SripadaIsrael Liberzon
Oct 11, 2012·Nature Reviews. Neuroscience·Roger K PitmanIsrael Liberzon
Mar 14, 2013·Cognitive, Affective & Behavioral Neuroscience·Peggy L St JacquesDavid C Rubin
May 15, 2013·NeuroImage·Yury KoushFrank Scharnowski
May 16, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ashley C Chen, Amit Etkin
May 21, 2013·The Medical Journal of Australia·Robert M Parker

❮ Previous
Next ❯

Citations

Aug 11, 2020·Frontiers in Behavioral Neuroscience·Karina QuevedoKathrin Cohen Kadosh
Nov 19, 2019·Frontiers in Psychiatry·Leon Skottnik, David E J Linden
May 15, 2019·Journal of Psychiatric Research·Amy GarrettW Stewart Agras

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.