Intrinsic dorsoventral patterning and extrinsic EGFR signaling genes control glial cell development in the Drosophila nervous system

Neuroscience
H J KimS H Kim

Abstract

Dorsoventral patterning and epidermal growth factor receptor (EGFR) signaling genes are essential for determining neural identity and differentiation of the Drosophila nervous system. Their role in glial cell development in the Drosophila nervous system is not clearly established. Our study demonstrated that the dorsoventral patterning genes, vnd, ind, and msh, are intrinsically essential for the proper expression of a master glial cell regulator, gcm, and a differentiation gene, repo, in the lateral glia. In addition, we showed that esg is particularly required for their expression in the peripheral glia. These results indicate that the dorsoventral patterning and EGFR signaling genes are essential for identity determination and differentiation of the lateral glia by regulating proper expression of gcm and repo in the lateral glia from the early glial development. In contrast, overexpression of vnd, msh, spi, and Egfr genes repressed the expression of Repo in the ventral neuroectoderm, indicating that maintenance of correct columnar identity along the dorsoventral axis by proper expression of these genes is essential for restrictive formation of glial precursor cells in the lateral neuroectoderm. Therefore, the dorsoventral pa...Continue Reading

References

Aug 1, 1996·Mechanisms of Development·M D'Alessio, M Frasch
Jul 14, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K M Bhat
Feb 19, 2000·Current Opinion in Neurobiology·R A Cornell, T V Ohlen
Oct 13, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B W Jones
Feb 21, 2003·Current Opinion in Neurobiology·James B Skeath, Stefan Thor
Jul 18, 2003·Cell Biology International·Santiago Nahuel VillegasNéstor Gabriel Carri
Oct 12, 2004·Trends in Neurosciences·Carole Chotard, Iris Salecker
Feb 22, 2005·Current Opinion in Neurobiology·Gundula EdenfeldChristian Klämbt
Dec 27, 2005·Trends in Neurosciences·Marc R Freeman, Johnna Doherty
Jan 20, 2006·Seminars in Cell & Developmental Biology·Robert J Parker, Vanessa J Auld
Feb 13, 2007·The International Journal of Developmental Biology·Guoyan ZhaoJames B Skeath
May 8, 2007·Neuron·Freda D Miller, Andrée S Gauthier
Dec 14, 2007·Mechanisms of Development·Christian M von HilchenBenjamin Altenhein
Feb 26, 2008·Mechanisms of Development·Ruth M BeckervordersandforthGerhard M Technau
Jul 19, 2008·Neuron Glia Biology·Laurent Soustelle, Angela Giangrande
Feb 13, 2010·Annual Review of Physiology·Michael M Halassa, Philip G Haydon
Jun 16, 2010·Brain Research Reviews·Alexei VerkhratskyJosé J Rodríguez
Nov 12, 2010·Nature·David H Rowitch, Arnold R Kriegstein
Oct 11, 2011·Developmental Biology·Cade MosesTonia Von Ohlen
Dec 24, 2011·Cold Spring Harbor Protocols·Tobias StorkMarc R Freeman
Jul 31, 2012·Developmental Biology·Haian MaoMargaret S Ho
Jan 9, 2014·Nature Reviews. Neuroscience·Minoree Kohwi, Chris Q Doe
Jul 6, 2014·Cell·Michael W Salter, Simon Beggs
May 1, 1995·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Kei ItoGerhard Martin Technau

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