Intrinsic features of Aedes aegypti genes affect transcriptional responsiveness of mosquito genes to dengue virus infection.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
S K Behura, David W Severson

Abstract

Dengue virus infection causes significant morbidity and mortality in humans world-wide. The Aedes aegypti mosquito is the major vector that spreads dengue virus to humans. Interaction between dengue viruses and A. aegypti is a multi-factorial phenomena that is determined by both virus and mosquito genotypes. Although, studies have suggested significant association of mosquito vectorial capacity with population variation of dengue virus, specifications of the vector factors that may influence vector-virus compatibility are very limited in the literature. Recently, we have shown that a large number of genes are differentially expressed between MOYO-S (susceptible) and MOYO-R (refractory) A. aegypti strains upon infection with dengue virus (JAM-1409 genotype). In the current study, we show that specific intrinsic features of A. aegypti genes are significantly associated with 'responsiveness' of mosquito genes to dengue infection. Binomial logistic regression analysis further reveals differential marginal effects of these features on gene responsiveness of mosquitoes to the viral infection. Thus, our result shows that intrinsic features of genes significantly affect differential expression of A. aegypti genes to dengue infection. T...Continue Reading

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Citations

Jan 25, 2013·International Journal of Environmental Research and Public Health·Walter J Tabachnick
May 7, 2014·Functional & Integrative Genomics·Susanta K BehuraDavid W Severson
Jun 19, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Olaf RodriguezSusanta K Behura
Nov 20, 2015·Journal of Immunology Research·Juan Santiago Salas-Benito, Mónica De Nova-Ocampo
Oct 23, 2015·PLoS Pathogens·Berlin Londono-RenteriaTonya M Colpitts
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Aug 15, 2012·Biological Reviews of the Cambridge Philosophical Society·Susanta K Behura, David W Severson
Mar 16, 2019·Annals of Global Health·Victor Hugo Peña-GarcíaOmar Triana-Chavez

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