Abstract
Traditional risk factors, e.g. hyperlipidemia, cigarette consumption, blood pressure, family history, and diabetes, predict < 50% of all future cardiovascular events. This paper reviews the use of novel hemostatic and thrombotic markers, such as intrinsic fibrinolysis and systemic micro-inflammation, for the prediction of the risk of arterial thrombotic disease. It has been hypothesized that relative abnormalities in the hemostatic and thrombotic systems are common on a population basis, and that they predispose certain individuals to clinically pathologic thrombosis. Abnormal levels of fibrinolytic parameters have been shown to predict future cardiovascular events, and tissue-type plasminogen activator antigen appears to be the most useful of these markers. Low-grade chronic inflammation may play an important role in atherogenesis. Of the newer inflammatory parameters, C-reactive protein has been the best studied and evidence suggests that elevated levels of C-reactive protein can predict the future risk of both myocardial infarction and stroke, both in healthy individuals and in patients with known coronary artery disease. Results from clinical trials to evaluate whether modification of novel risk factors results in a net cli...Continue Reading
Citations
Jan 22, 2002·Journal of Psychosomatic Research·Paul H Black, Lisa D Garbutt
Apr 26, 2001·Thrombosis Research·A D Blann, G Y Lip
Jul 24, 2003·Journal of the American College of Cardiology·Yoshihiro FukumotoUNKNOWN Cholesterol Embolism Study(CHEST) Investigators
Sep 16, 2003·Clinical Obstetrics and Gynecology·Lawrence C Tsen
Oct 26, 1999·Journal of Endocrinological Investigation·N K Wenger, D Grady
Feb 1, 2000·Journal of Molecular and Cellular Cardiology·C StefanadisP Toutouzas
Mar 19, 2002·International Anesthesiology Clinics·Silvio E Inzucchi
Mar 27, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·R ZahnJ Senges
Mar 13, 2012·American Journal of Surgery·Daniel NelsonMatthew Martin
Jan 18, 2006·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Guoping M MaGarry X Shen
Jun 29, 1999·Cardiology Clinics·P K Shah
Jun 9, 2004·Anesthesiology Clinics of North America·Javier H Campos
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·Urmila P KodavantiDaniel L Costa
Aug 30, 2018·Current Opinion in Hematology·Alan Tyndall