Intrinsic frequency method for instantaneous assessment of left ventricular-arterial coupling after transcatheter aortic valve replacement.

Physiological Measurement
Emad MogadamNiema M Pahlevan

Abstract

Aortic stenosis (AS) is the most common cause for valve replacement in the United States. The pathophysiology of AS involves obstruction to the left ventricular (LV) outflow and reduced arterial compliance. The intrinsic frequency (IF) method is a system-based approach for hemodynamic monitoring of the LV-arterial system and involves determination of ω1 and ω2, which represent the dynamics of LV systolic and vascular function, respectively. Total frequency variation of the systemic circulation is the difference between these IFs (Δω = ω1- ω2). Our goal in this study was to investigate whether Δω, obtained from the ascending aortic pressure waveform, can be indicative of LV-arterial coupling after transcatheter aortic valve replacement (TAVR). Thirty patients undergoing elective TAVR for severe, symptomatic AS were included. We applied the IF method to assess the immediate effects of TAVR on LV-arterial coupling. Mean age was 86 ± 4 years, 50% were male with a mean aortic valve area of 0.7 cm2 and mean ejection fraction (EF) of 59 ± 7%. The results showed a significant decrease in Δω (47.6 to 9.5 bpm, p < 0.00001) and a significant increase in ω2 (51.9 to 84.6 bpm, p < 0.00001) immediately post TAVR. These preliminary findings i...Continue Reading

References

Aug 1, 1989·Circulation Research·H AsanoiT Kameyama
Jun 26, 2001·British Journal of Clinical Pharmacology·M F O'RourkeX J Jiang
Dec 12, 2001·Journal of the American College of Cardiology·C H ChenD A Kass
Apr 23, 2003·Hypertension·Francesco Antonini-CanterinGian Luigi Nicolosi
Jan 12, 2011·The International Journal of Cardiovascular Imaging·Vitantonio Di BelloAnna Sonia Petronio
Nov 2, 2013·Artery Research·Julio A Chirinos
Jul 11, 2014·Journal of the Royal Society, Interface·Niema M PahlevanMorteza Gharib
Jul 18, 2015·Journal of Diabetes Science and Technology·Danny PetrasekMorteza Gharib
Mar 29, 2016·Royal Society Open Science·Peyman TavallaliNiema M Pahlevan
Apr 5, 2016·The New England Journal of Medicine·Martin B LeonUNKNOWN PARTNER 2 Investigators
Nov 2, 2016·ClinicoEconomics and Outcomes Research : CEOR·Matt MooreJohn A Rizzo
Oct 1, 2013·Journal of Cardiovascular Echography·Francesco Antonini-CanterinGian Luigi Nicolosi
Jan 19, 2018·Scientific Reports·Peyman TavallaliNiema M Pahlevan
Mar 22, 2018·Scientific Reports·Peyman TavallaliJoanna Krupa
Jun 23, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Saro H ArmenianMorteza Gharib
Mar 19, 2019·The New England Journal of Medicine·Michael J MackUNKNOWN PARTNER 3 Investigators
Feb 29, 2020·Physiological Measurement·Derek RinderknechtNiema M Pahlevan

❮ Previous
Next ❯

Citations

May 22, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Jing Liu, Niema M Pahlevan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Trends in Cardiovascular Medicine
Andras P DurkoA Pieter Kappetein
Circulation Journal : Official Journal of the Japanese Circulation Society
In-Chang HwangHyo-Soo Kim
Minerva cardioangiologica
Lucia JunqueraJosep Rodés-Cabau
© 2021 Meta ULC. All rights reserved