Intrinsic Functional Plasticity of the Thalamocortical System in Minimally Disabled Patients with Relapsing-Remitting Multiple Sclerosis

Frontiers in Human Neuroscience
Fuqing ZhouChi-Shing Zee

Abstract

The thalamus plays a crucial role in sensorimotor, cognitive, and attentional circuit functions. Disruptions in thalamic connectivity are believed to underlie the symptoms of multiple sclerosis (MS). Therefore, assessing thalamocortical structural connectivity (SC) and functional connectivity (FC) may provide new insights into the mechanism of intrinsic functional plasticity in a large-scale neural network. We used resting-state FC measurement and diffusion tensor imaging probabilistic tractography to study the functional and structural integrity of the thalamocortical system in patients with relapsing-remitting MS (RRMS) and matched healthy controls. In the thalamocortical connections of RRMS patients, we found lesion load-related regional FC in the right temporal pole, which reflected compensatory hyperconnectivity related to lesion-related demyelination. We also found significant correlations between increased diffusivity and slowed cognitive processing (PASAT) or the impact of fatigue (MFIS-5), as well as between connective fiber loss and disease duration. Taken together, the evidence from SC and FC analysis of the thalamocortical system suggests that minimally disabled RRMS patients exhibit a dissociated SC-FC pattern and ...Continue Reading

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Citations

Jun 29, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Milagros Hidalgo de la CruzMaria Assunta Rocca
Sep 4, 2019·Postgraduate Medicine·Riccardo MancaAnnalena Venneri
May 30, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Fioravante CaponeMarcello Moccia
Oct 27, 2018·Frontiers in Neurology·Marlene TahedlJens V Schwarzbach
Feb 22, 2018·Neuroreport·Álvaro J Cruz-GómezCristina Forn
Mar 30, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Chencai WangBenjamin M Ellingson

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Software Mentioned

FMRIB
BEDPOSTX
DARTEL
AlphaSim
Matlab
SPM8
FMRIB Diffusion Toolbox ( FDT
Data Processing Assistant for Resting - State fMRI Advanced Ed...
MRIcron
SPSS

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