PMID: 22216520Dec 1, 1976Paper

Intrinsic heart rate on exercise and the measurement of beta-adrenoceptor blockade

British Journal of Clinical Pharmacology
S G CarruthersD G McDevitt


Methods of expressing the effects of beta-adrenoceptor blocking drugs on exercise heart rate have been evaluated using a standardised exercise test. In six normal subjects given atropine (0.04 mg/kg) on two separate occasions, the mean +/- s.e. mean exercise heart rate rose by 10.3 +/- 1.8 beats/min and by 11.0 +/- 1.6 beats/min respectively. This increase was designated the 'vagal effect and was not significantly different in the two studies. After atropinsation, propranolol (0.2 mg/kg) reduced mean +/- s.e. mean exercise heart rate by 45.3 +/- 2.6 beats/min and 0.4 mg/kg by 50.8 +/- 4.5 beats/min. This mean sympathetic blockade was not altered significantly by increasing the dose of propranolol but, in four of the six subjects, the larger dose produced an increased effect of 4, 6, 12 and 16 beats/min, suggesting that maximum sympathetic blockade may not have been produced by 0.2 mg/kg. Knowledge of the vagal effect in each subject with standardised exercise enabled prediction to be made of the exercise heart rate after propranolol (0.4 mg/kg) without previous atropinisation. Propranolol (0.4 mg/kg) was then given intravenously to each subject and the actual exercise heart rate measured. There was no significant difference bet...Continue Reading


Apr 1, 1973·The Journal of Clinical Investigation·G BodemC A Chidsey
Jul 1, 1967·Lancet·D A ChamberlainJ M Sneddon
Apr 1, 1970·Cardiovascular Research·A D Jose, D Collison
Nov 7, 1974·The New England Journal of Medicine·K M Kent, T Cooper
May 1, 1970·British Journal of Pharmacology·J M Kofi EkueR G Shanks
Sep 26, 1970·British Medical Journal·D J Coltart, D G Shand
Jan 1, 1973·Clinical Pharmacology and Therapeutics·G Bodem, C A Chidsey
May 1, 1974·Clinical Pharmacology and Therapeutics·S G CarruthersR G Shanks
Mar 1, 1953·Journal of Applied Physiology·S ROBINSOND I MILLER


Jan 1, 1991·European Journal of Clinical Pharmacology·B J LipworthD G McDevitt
Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·M StäubliP W Straub
Jan 1, 1983·European Journal of Clinical Pharmacology·T IshizakiK Kushida
Nov 9, 1978·European Journal of Clinical Pharmacology·T Ishizaki, K Tawara
Jul 26, 1974·European Journal of Clinical Pharmacology·C R Kumana, C M Kaye
Jan 1, 1979·European Journal of Clinical Pharmacology·G NybergA Vedin
Nov 1, 1990·Journal of the American College of Cardiology·L ToivonenF Morady
Aug 1, 1977·British Journal of Clinical Pharmacology·D G McDevitt
Oct 1, 1978·British Journal of Clinical Pharmacology·M A MartinA J Smith
Mar 1, 1979·British Journal of Clinical Pharmacology·G L JenningsP I Korner
Nov 1, 1991·British Journal of Clinical Pharmacology·H KelbaekS L Nielsen
Feb 1, 1991·British Journal of Clinical Pharmacology·B J LipworthD G McDevitt
Apr 1, 1992·British Journal of Clinical Pharmacology·N M WheeldonB J Lipworth
Oct 1, 1992·British Journal of Clinical Pharmacology·N M WheeldonB J Lipworth
Aug 1, 1994·British Journal of Clinical Pharmacology·N M WheeldonB J Lipworth
Mar 1, 1985·British Journal of Clinical Pharmacology·P C O'ConnorR G Shanks
Jan 1, 1982·British Journal of Clinical Pharmacology·S G Carruthers
Jan 1, 1982·British Journal of Clinical Pharmacology·A SvenssonL Hansson
May 1, 1981·British Journal of Clinical Pharmacology·D W Harron, R G Shanks
Nov 1, 1977·Irish Journal of Medical Science·D G McDevitt
Jan 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·J H Atterhög, L G Ekelund

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.