Intrinsic mechanisms for adaptive gain rescaling in barrel cortex

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Marta Díaz-Quesada, Miguel Maravall

Abstract

Barrel cortex neuronal responses adapt to changes in the statistics of complex whisker stimuli. This form of adaptation involves an adjustment in the input-output tuning functions of the neurons, such that their gain rescales depending on the range of the current stimulus distribution. Similar phenomena have been observed in other sensory systems, suggesting that adaptive adjustment of responses to ongoing stimulus statistics is an important principle of sensory function. In other systems, adaptation and gain rescaling can depend on intrinsic properties; however, in barrel cortex, whether intrinsic mechanisms can contribute to adaptation to stimulus statistics is unknown. To examine this, we performed whole-cell patch-clamp recordings of pyramidal cells in acute slices while injecting stochastic current stimuli. We induced changes in statistical context by switching across stimulus distributions. The firing rates of neurons adapted in response to changes in stimulus statistics. Adaptation depended on the form of the changes in stimulus distribution: in vivo-like adaptation occurred only for rectified stimuli that maintained neurons in a persistent state of net depolarization. Under these conditions, neurons rescaled the gain of...Continue Reading

Citations

Feb 4, 2009·Biological cybernetics·Rasmus S PetersenMiguel Maravall
Oct 22, 2008·Nature Neuroscience·Brian N LundstromAdrienne L Fairhall
Sep 21, 2010·Cerebral Cortex·Juan M AbolafiaM V Sanchez-Vives
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Dec 19, 2013·PloS One·Miguel MaravallRasmus S Petersen
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Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

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