Intrinsic nucleoside diphosphate kinase-like activity as a novel function of 14-3-3 proteins

FEBS Letters
M YanoH Kido

Abstract

14-3-3 proteins play a role in many cellular functions as molecular chaperone and adapter proteins: they bind to and modulate several proteins involved in cell proliferation and differentiation, and also function ATP-dependently in targeting of precursors to mitochondria. We show here that 14-3-3 purified from a human lymphoblastoma and also its recombinant tau isoform exhibited intrinsic nucleoside diphosphate (NDP) kinase-like activity. 14-3-3 proteins preferentially catalyzed the transfer of the gamma-phosphate group from ATP, dATP or dGTP to all nucleoside diphosphates and this transfer involved acid-labile phosphoenzyme intermediates. They also simultaneously catalyzed the reverse reaction of ATP hydrolysis. These properties of 14-3-3 are similar to those of NDP kinase, but not to those of adenylate kinase.

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Citations

Aug 30, 2002·Biochemical and Biophysical Research Communications·Seong Hwan KimGert Lubec
Oct 3, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·H WakabayashiH Kido
Jan 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brijesh S AjjappalaKwang-Hyun Baek

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