Intrinsic overlapping modular organization of human brain functional networks revealed by a multiobjective evolutionary algorithm

NeuroImage
Ying LinZhengjia Dai

Abstract

A wealth of research on resting-state functional MRI (R-fMRI) data has revealed modularity as a fundamental characteristic of the human brain functional network. The modular structure has recently been suggested to be overlapping, meaning that a brain region may engage in multiple modules. However, not only the overlapping modular structure remains inconclusive, the topological features and functional roles of overlapping regions are also poorly understood. To address these issues, the present work utilized the maximal-clique based multiobjective evolutionary algorithm to explore the overlapping modular structure of the R-fMRI data obtained from 57 young healthy adults. Without prior knowledge, brain regions were optimally grouped into eight modules with wide overlap. Based on the topological features captured by graph theory analyses, overlapping regions were classified into an integrated club and a dominant minority club through clustering. Functional flexibility analysis found that overlapping regions in both clubs were significantly more flexible than non-overlapping ones. Lesion simulations revealed that targeted attack at overlapping regions were more damaging than random failure or even targeted attack at hub regions. In...Continue Reading

References

Jan 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K J FristonR S Frackowiak
Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Jul 2, 1998·Brain : a Journal of Neurology·M M Mesulam
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sophie AchardEd Bullmore
Jun 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Nico U F DosenbachSteven E Petersen
Aug 21, 2007·Nature Reviews. Neuroscience·Michael D Fox, Marcus E Raichle
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
May 2, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yong HeAlan Evans
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Apr 3, 2009·Journal of Neurophysiology·Michael D FoxMarcus E Raichle
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Dec 29, 2009·NeuroImage·Andrew ZaleskyEdward T Bullmore
May 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Dardo Tomasi, Nora D Volkow
Apr 14, 2011·Annals of the New York Academy of Sciences·Gagan S WigSteven E Petersen
Apr 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Danielle S BassettScott T Grafton
May 26, 2011·NeuroImage·Dardo Tomasi, Nora D Volkow
Jun 10, 2011·Journal of Neurophysiology·B T Thomas YeoRandy L Buckner
Nov 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martijn P van den Heuvel, Olaf Sporns
Nov 22, 2011·Neuron·Jonathan D PowerSteven E Petersen
Jun 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Martijn P van den HeuvelOlaf Sporns
Nov 14, 2012·Cerebral Cortex·Elena A AllenVince D Calhoun
Jan 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Xia LiangYihong Yang
Jun 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Nicolas A CrossleyEdward T Bullmore
Jul 31, 2013·Nature Neuroscience·Michael W ColeTodd S Braver
Sep 25, 2014·Cerebral Cortex·B T Thomas YeoMichael W L Chee
Apr 8, 2015·Nature Neuroscience·Danielle S BassettScott T Grafton
May 6, 2015·Annual Review of Neuroscience·Marcus E Raichle
Jun 16, 2015·Neuroscience and Biobehavioral Reviews·Peter H DonaldsonPeter G Enticott
Sep 24, 2015·Annual Review of Psychology·Olaf Sporns, Richard F Betzel
Nov 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Maxwell A BertoleroMark D'Esposito

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