PMID: 8592176Nov 1, 1995Paper

Intrinsic properties of deep dorsal horn neurons in the L6-S1 spinal cord of the intact rat

Journal of Neurophysiology
M C JiangG F Gebhart

Abstract

1. Stable intracellular recordings were obtained from neurons (n = 62) in the L6-S1 deep dorsal horn of the spinal cord in pentobarbital-sodium-anesthetized, intact rats (n = 26). All neurons responded to natural mechanical stimuli and/or electrical stimulation of peripheral afferents. 2. Intracellular penetrations were maintained for 30 min-2 h. Action potentials occurred spontaneously in most neurons (n = 50) and could be evoked in the remainder (n = 12) by depolarizing current passage. Mean resting membrane potential was -60.9 mV, mean action potential height amplitude was 75.2 mV, mean half-width of the action potentials was 0.33 ms, mean input resistance was 38 M omega, and mean time constant was 9.1 ms. 3. Action potentials were followed by afterpotentials made up of at least three components; a fast afterhyperpolarization (fAHP), a slow afterhyperpolarization (sAHP), and an afterdepolarization (ADP). Most neurons (n = 40) exhibited all three afterpotentials, although some displayed only a fAHP and an ADP (n = 10) or a fAHP and a sAHP (n = 12). The durations and magnitudes of the afterpotentials varied widely among neurons. 4. Steady-state current-voltage relations were investigated in 14 neurons with depolarizing and hyp...Continue Reading

Citations

Dec 25, 2003·The Journal of Physiology·Ruth RuscheweyhJürgen Sandkühler
Feb 15, 2007·The Journal of Comparative Neurology·Stephen P Schneider, Tracy M Walker
Dec 29, 2006·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·E K StaufferD G Stuart
Jun 16, 1999·Journal of Neurophysiology·M C JiangG F Gebhart
Jan 11, 2008·Journal of Neurophysiology·Stephen P Schneider
Apr 4, 2009·Physiological Reviews·Jürgen Sandkühler
May 17, 2002·The Journal of Physiology·Ruth Ruscheweyh, Jürgen Sandkühler
Oct 16, 2001·Journal of Neurophysiology·D J BennettM Siu
Feb 20, 2003·Nature Neuroscience·Dominique DerjeanFrédéric Nagy
Feb 19, 2017·British Journal of Pharmacology·Olivier Roca-LapirotPascal Fossat
Dec 22, 1999·Progress in Biophysics and Molecular Biology·R E Russo, J Hounsgaard

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