PMID: 9416792Jan 7, 1998Paper

Intrinsic radiosensitivity of healthy donors and cancer patients as determined by the lymphocyte micronucleus assay

International Journal of Radiation Biology
D Słonina, A Gasińska

Abstract

The purpose of the study was to evaluate the usefulness of the cytokinesis-block micronucleus (MN) assay in assessment of radiosensitivity of lymphocytes in cancer patients. Lymphocytes from 15 cervical cancer patients, 21 head and neck cancer patients, seven lung cancer patients and 19 healthy donors were analysed using MN assay. The proportion of binucleate cells (BC) in cancer patients ranged from 22 to 56% and was significantly lower than in the control group (38-68%). MN frequency assessed five times over 6 months in four healthy donors showed that the interindividual variation was significantly higher than intraindividual. Before (0 Gy) and after irradiation (2 and 4 Gy) no statistical differences in the mean number of MN/BC were observed between healthy donors and cancer patient groups. Nevertheless, statistical cluster analysis allowed each group of donors to be divided into radioresistant and radiosensitive subgroups of patients. They showed significantly different dose response. Separate comparison of the mean MN frequency within all examined radioresistant and radiosensitive subgroups, showed statistically significant differences only after a dose of 4 Gy. At this dose, the lung cancer patients and cervical cancer pa...Continue Reading

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Citations

Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Tung-Kwang LeeUlf L Karlsson
Apr 30, 2003·Radiation and Environmental Biophysics·Dorota SłoninaWolfgang Dörr
Sep 28, 2010·Critical Reviews in Oncology/hematology·D AzriaM Ozsahin
Jul 6, 2010·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·D AzriaM Ozsahin
Jan 18, 2016·Advanced Drug Delivery Reviews·Philippe LambinSean Walsh
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·J WangD F Deen
Sep 5, 2020·Animal Science Journal = Nihon Chikusan Gakkaihō·Marta Kuchta-GładyszPiotr Niedbała
May 15, 2002·Radiation Research·Tung-Kwang LeeAlbert L Wiley
Oct 5, 2017·Nature Reviews. Clinical Oncology·Philippe LambinSean Walsh
Oct 29, 2018·Archives Animal Breeding·Olga SzeleszczukAgnieszka Otwinowska-Mindur
Sep 19, 2000·International Journal of Radiation Biology·D SloninaA Gasinska
Nov 21, 2012·Nature Reviews. Clinical Oncology·Philippe LambinAndre Dekker
Oct 26, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mahmut OzsahinDavid Azria

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