Intrinsic Raman spectroscopy for quantitative biological spectroscopy part I: theory and simulations.

Optics Express
Wei-Chuan ShihM S Feld

Abstract

We present a novel technique, intrinsic Raman spectroscopy (IRS), to correct turbidity-induced Raman spectral distortions, resulting in the intrinsic Raman spectrum that would be observed in the absence of scattering and absorption. We develop an expression relating the observed and intrinsic Raman spectra through diffuse reflectance using the photon migration depiction of light transport. Numerical simulations are employed to validate the theoretical results and study the dependence of this expression on sample size and elastic scattering anisotropy.

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Citations

Mar 26, 2014·Methods : a Companion to Methods in Enzymology·Alasdair RaeDebdulal Roy
May 6, 2009·Analytical Chemistry·Ishan BarmanMichael S Feld
Apr 16, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·H Wolfgang BeumerWalter T Lee
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Jun 12, 2010·Applied Spectroscopy·Matthew D KellerAnita Mahadevan-Jansen
May 23, 2015·Journal of Biophotonics·Jingting LiWei-Chuan Shih
Jul 1, 2017·Biomedical Optics Express·Xu FengJames W Tunnell
Mar 15, 2016·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Ilya KrasnikovMerve Meinhardt-Wollweber
Dec 15, 2017·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Ilya KrasnikovBernhard Roth
May 3, 2019·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Ilya KrasnikovBernhard Roth
Jun 6, 2013·Optics Express·Brett H Hokr, Vladislav V Yakovlev
Jul 10, 2010·Journal of Biomedical Optics·Carina RebleJürgen Helfmann
Aug 29, 2019·Biomedical Engineering Letters·Ilya KrasnikovBernhard Roth
Feb 18, 2015·Journal of Biomedical Optics·Wei-Chuan ShihMihailo V Rebec
Mar 9, 2021·Biomedical Optics Express·Isaac J PenceAnita Mahadevan-Jansen

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