Intrinsic vasomotricity and adrenergic effects in a model of isolated rabbit eye

Acta Ophthalmologica
Esmeralda DelgadoLuis Silva-Carvalho

Abstract

We aimed to investigate the responsiveness of the ocular arteries to adrenergic drugs in a model of perfused isolated rabbit eye. Rabbit external ophthalmic arteries (n = 15) in a head-mounted preparation were cannulated and the retinal and uveal vasculature perfused at a constant flow with warmed tyrode. The three-way polypropylene catheter was further connected to a pressure transducer and intraluminal pressure was taken as a measure of vascular resistance. Effects of intra-arterial injections of phenylephrine (group A, n = 5), prazosin (group B, n = 5) and phentolamine (group C, n = 5) on the recorded pressure were obtained. Student's paired-t test and one-way analysis of variance were used for statistical analysis (p < 0.05). Intrinsic vasomotricity was observed in all preparations prior to any drug administration. Phenylephrine produced an increase in total vascular resistance. Intrinsic vasomotricity became more evident, showing a lower frequency but higher amplitude of oscillations. Evoked vasomotor responses with phenylephrine (250 microg/ml) were inhibited by intra-arterial administration of the selective alpha(1)-adrenergic antagonist, prazosin (0.5 mg/ml), as well as the non-selective alpha-adrenergic antagonist phen...Continue Reading

References

Jan 1, 1990·Eye·A Bill, G O Sperber
May 1, 1987·Documenta Ophthalmologica. Advances in Ophthalmology·P Gasser, J Flammer
May 1, 1994·Experimental Eye Research·J W Kiel
May 1, 1997·British Journal of Clinical Pharmacology·K KrejcyL Schmetterer
Jan 7, 1999·European Journal of Pharmacology·M Kawarai, M C Koss
Oct 3, 1999·Experimental Eye Research·J W Kiel
Feb 2, 2000·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·E J RoffL Kagemann
Feb 16, 2000·International Ophthalmology·P Gasser
Jul 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J J SteinleP G Smith
Oct 3, 2000·Ophthalmic Research·C Delaey, J Van De Voorde
Nov 30, 2000·Experimental Eye Research·J W Kiel
Apr 5, 2001·Progress in Retinal and Eye Research·G Niemeyer
Feb 27, 2003·Progress in Retinal and Eye Research·Dao-Yi YuPaula K Yu
Jun 5, 2003·Acta Ophthalmologica Scandinavica·Anders HessellundToke Bek
Oct 17, 2003·Current Eye Research·Peter JeppesenToke Bek
Dec 24, 2003·Investigative Ophthalmology & Visual Science·Yagna P R JarajapuHarm J Knot
Jan 25, 2006·Investigative Ophthalmology & Visual Science·Isamu ItoHarm J Knot
Aug 29, 2006·Investigative Ophthalmology & Visual Science·Konstantin GugletaSelim Orgul
May 10, 2007·Acta Ophthalmologica Scandinavica·Peter JeppesenToke Bek

❮ Previous
Next ❯

Citations

Nov 19, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Esmeralda DelgadoLuís Silva-Carvalho
Feb 24, 2009·American Journal of Ophthalmology·Ron Margolis, Richard F Spaide
Feb 4, 2012·Clinical & Experimental Ophthalmology·Kazuyuki HirookaFumio Shiraga
Aug 12, 2009·Acta Ophthalmologica·Esmeralda DelgadoLuis Silva-Carvalho
Apr 13, 2012·Journal of Ophthalmology·Esmeralda Sofia Costa DelgadoLuís Filipe Silva-Carvalho
Nov 22, 2017·Acta Ophthalmologica·David Cordeiro SousaCarlos Marques-Neves
Jun 27, 2019·Alternatives to Laboratory Animals : ATLA·Sven SchnichelsStephanie C Joachim
May 20, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Kento WatanabeYuichi Hori

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)
Seang-Mei SawWei-Han Chua
Clinical & Experimental Optometry : Journal of the Australian Optometrical Association
Ian G Morgan
© 2022 Meta ULC. All rights reserved