Intrinsic vesicular glutamate transporter 2-immunoreactive input to septohippocampal parvalbumin-containing neurons: novel glutamatergic local circuit cells

Hippocampus
Tibor HajszanC Leranth

Abstract

Glutamatergic influence on the medial septum diagonal band of Broca complex (MSDB) is a crucial and powerful driver of hippocampal theta rhythm and associated memory processes, in the rat. The recent discovery of vesicular glutamate transporters (VGLUT) provided a specific marker for glutamatergic neuronal elements. Therefore, this study aimed to address two specific questions: (1) do glutamatergic axons innervate MSDB gamma-aminobutyric acid (GABA)ergic, parvalbumin (PV)-containing septohippocampal neurons that are known to have a great influence on the electric activity of the hippocampus; and (2) is the origin of these glutamatergic axons extrinsic and/or intrinsic to the septum. The results of the correlated light and electron microscopic double-labeling immunohistochemistry for VGLUT2 and PV, and single immunostaining for VGLUT2 in colchicine-treated animals, showed that (1) VGLUT2-containing boutons establish asymmetric synaptic contacts with PV-positive perikarya and dendrites; (2) a large population of VGLUT2-immunoreactive neurons is located primarily in the posterior division of the septum; and (3) following surgical fimbria/fornix transection and septal undercut, most VGLUT2-containing axons, including those terminat...Continue Reading

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Citations

Sep 9, 2005·Hippocampus·Robert P Vertes
Aug 10, 2006·Journal of Computational Neuroscience·Balázs Ujfalussy, Tamás Kiss
Mar 26, 2013·Acta Pharmacologica Sinica·Cheng-biao LuZaineb Henderson
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Oct 4, 2011·Journal of Physiology, Paris·Michele PignatelliXavier Leinekugel
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Jan 13, 2006·Journal of Neurochemistry·Luis V Colom
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Jun 1, 2005·Brain Research Bulletin·Attila TóthLászló Détári
Jun 17, 2015·Experimental Neurology·Raquel Garcia-LopezSalvador Martinez
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Sep 4, 2014·Brain Structure & Function·Raúl Peñas-Cazorla, M Teresa Vilaró
Apr 9, 2015·Frontiers in Neuroanatomy·Álvaro García-AvilésFrancisco Olucha-Bordonau
Sep 4, 2007·Progress in Brain Research·Csaba Leranth, Tibor Hajszan
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Dec 19, 2017·Cell and Tissue Research·Christina Müller, Stefan Remy
Aug 10, 2018·Scientific Reports·Mohammed Zacky AriffinSanjay Khanna
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Feb 25, 2018·Neurobiology of Learning and Memory·Gürsel Çalışkan, Oliver Stork
Jun 29, 2021·Frontiers in Neural Circuits·Khairunisa Mohamad IbrahimSanjay Khanna

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