Intrinsically radiopaque iodine-containing polyvinyl alcohol as a liquid embolic agent: evaluation in experimental wide-necked aneurysms

Journal of Neurosurgery
O DudeckR Felix

Abstract

To evaluate iodine-containing polyvinyl alcohol (I-PVA) as a precipitating liquid embolic agent, implant characteristics--including radiopacity, setting behavior, and biocompatibility--were studied in an aneurysm model in swine. Twelve broad-based carotid artery (CA) sidewall aneurysms were surgically constructed in six pigs. Iodine-containing polyvinyl alcohol dissolved in dimethyl sulfoxide (DMSO) was injected during temporary balloon occlusion bridging the aneurysm neck. Control angiography as well as multidetector row computerized tomography (CT) angiography was performed after 4 weeks. Harvested aneurysms were investigated histopathologically and by 3-tesla high-field magnetic resonance (MR) imaging. The mean degree of aneurysm occlusion achieved was 96%. In two aneurysms a minimal protrusion of I-PVA into the CA lumen was observed. During one embolization, leakage of the liquid embolic agent due to DMSO-induced damage of the microcatheter resulted in CA occlusion. Aneurysms embolized with I-PVA could be discriminated clearly from the parent artery on CT angiograms because there was no beam-hardening artifact. High-field MR imaging allowed a detailed depiction of the liquid embolic distribution within the aneurysm. Histolo...Continue Reading

References

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Citations

Dec 28, 2010·Journal of Vascular and Interventional Radiology : JVIR·Brad P Barnett, Philippe Gailloud
Oct 1, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Michael J ConstantGregory M Cruise
Feb 14, 2015·Acta Odontologica Scandinavica·Huaiguang ChangHailan Feng
Oct 7, 2021·Journal of Biomaterials Science. Polymer Edition·Seong Ik JeonCheol-Hee Ahn

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