Intrinsically regulated learning is modulated by synaptic dopamine signaling

ELife
Pablo RipollésAntoni Rodríguez-Fornells

Abstract

We recently provided evidence that an intrinsic reward-related signal-triggered by successful learning in absence of any external feedback-modulated the entrance of new information into long-term memory via the activation of the dopaminergic midbrain, hippocampus, and ventral striatum (the SN/VTA-Hippocampal loop; Ripollés et al., 2016). Here, we used a double-blind, within-subject randomized pharmacological intervention to test whether this learning process is indeed dopamine-dependent. A group of healthy individuals completed three behavioral sessions of a language-learning task after the intake of different pharmacological treatments: a dopaminergic precursor, a dopamine receptor antagonist or a placebo. Results show that the pharmacological intervention modulated behavioral measures of both learning and pleasantness, inducing memory benefits after 24 hr only for those participants with a high sensitivity to reward. These results provide causal evidence for a dopamine-dependent mechanism instrumental in intrinsically regulated learning and further suggest that subject-specific reward sensitivity drastically alters learning success.

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Citations

Jan 24, 2019·Proceedings of the National Academy of Sciences of the United States of America·Laura FerreriAntoni Rodriguez-Fornells
Oct 2, 2020·Scientific Reports·Gemma CardonaLaura Ferreri
May 14, 2021·Neuropsychology Review·David A CoplandAnthony J Angwin
Jun 25, 2021·Scientific Reports·Nihaad ParaoutyDan H Sanes
Jul 12, 2021·Annals of the New York Academy of Sciences·Laura FerreriAntoni Rodriguez-Fornells
Jun 7, 2019·Neuron·Frank KoopmansMatthijs Verhage

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