Introducing FDG PET/CT-guided chemoradiotherapy for stage III NSCLC in low- and middle-income countries: preliminary results from the IAEA PERTAIN trial

European Journal of Nuclear Medicine and Molecular Imaging
Tom KonertGerard G Hanna

Abstract

Patients with stage III non-small-cell lung cancer (NSCLC) treated with chemoradiotherapy (CRT) in low- and middle-income countries (LMIC) continue to have a poor prognosis. It is known that FDG PET/CT improves staging, treatment selection and target volume delineation (TVD), and although its use has grown rapidly, it is still not widely available in LMIC. CRT is often used as sequential treatment, but is known to be more effective when given concurrently. The aim of the PERTAIN study was to assess the impact of introducing FDG PET/CT-guided concurrent CRT, supported by training and quality control (QC), on the overall survival (OS) and progression-free survival (PFS) of patients with stage III NSCLC. The study included patients with stage III NSCLC from nine medical centres in seven countries. A retrospective cohort was managed according to local practices between January 2010 and July 2014, which involved only optional diagnostic FDG PET/CT for staging (not for TVD), followed by sequential or concurrent CRT. A prospective cohort between August 2015 and October 2018 was treated according to the study protocol including FDG PET/CT in treatment position for staging and multimodal TVD followed by concurrent CRT by specialists tra...Continue Reading

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Citations

Jul 28, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Myra van LaarJoost J C Verhoeff
Mar 8, 2021·The Lancet Oncology·Hedvig HricakAndrew M Scott
Apr 6, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jean-Pierre BissonnetteMichael Mac Manus
Jun 9, 2021·JCO Global Oncology·May Abdel-WahabMary Gospodarowicz
May 30, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Abdul Rahman JaziehByoung-Chul Cho

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Clinical Trials Mentioned

NCT02247713

Software Mentioned

PERTAIN
SPSS

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