Introducing national guidelines on perioperative chemotherapy for gastric cancer in Norway: a retrospective audit

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
T HølmebakkNorwegian Gastrointestinal Cancer Group (NGICG)

Abstract

In 2006, perioperative chemotherapy with epirubicin, cisplatin/oxaliplatin, and capecitabine was recommended in the National Guidelines for patients with resectable gastric cancer in Norway. We conducted a national audit related to clinical aspects, local organisation and the implementation of this multimodal treatment. All Norwegian departments of oncology were asked to submit aggregated data on gastric cancer patients who had started perioperative chemotherapy for cure; departments of surgery were asked to report on patients undergoing resection after preoperative chemotherapy. Data were retrospectively collected. All 20 departments of oncology and 20 of 21 departments of surgery responded. Of 336 patients operated on for gastric cancer and reported by surgeons, 144 (43%) received preoperative chemotherapy. 169 patients were reported by departments of oncology. 152 (90%) completed the preoperative cycles; 92 (54%) started the postoperative cycles; and 68 (40%) completed all cycles. Toxicity grade >or= 3, overall and haematological, increased during postoperative compared to preoperative cycles, 50 vs. 34% (P = 0.012) and 35 vs. 20% (P = 0.012), respectively. Surgical morbidity and mortality were 26 and <2%, respectively. R0 r...Continue Reading

References

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Citations

Jul 11, 2012·International Journal of Cancer. Journal International Du Cancer·Vincent K Y HoHenk H Hartgrink
Jan 22, 2013·Journal of Surgical Oncology·E A BringelandJ E Grønbech
Sep 7, 2014·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Markus MoehlerStefan P Mönig
Mar 10, 2017·Scandinavian Journal of Gastroenterology·Erling A BringelandJon E Grønbech
Mar 22, 2015·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·M P AchiamL B Svendsen
Oct 15, 2014·The British Journal of Surgery·E A BringelandJ E Grønbech

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