Introduction of new formulas and evaluation of the previous red blood cell indices and formulas in the differentiation between beta thalassemia trait and iron deficiency anemia in the Makkah region

Hematology
Amal ZaghloulGhada A Wassif

Abstract

Many formulas from red blood cell (RCB) indices are instructed to differentiate between iron deficiency anemia (IDA) and beta thalassemia trait. None had 100% Youden index. To introduce two new formulas and evaluate them in the differentiation between IDA and beta thalassemia trait in adults Saudi (male and female; male; female) in the Makkah region. Furthermore, to evaluate the previous formulas in our population. A total of 249 participants, 91 with IDA, 123 with beta thalassemia trait, and 35 healthy persons. All subjected to complete blood count, measurement of iron profile, hemoglobin electrophoresis and hemoglobin A2 by column chromatography. The first new formula equal hemoglobin (Hb) + hematocrit (Hct) + RBC and second equals Hb + Hct + RBC-red cell distribution (RDW). The previous formula used is England and Fraser, Mentzer, Strivastava, Ehsani, Green and King, red cell distribution index, Ricerca, and Shine and Lal Results: In both men and women, the England and Fraser was the best with a Youden's index of 70.4%, followed by Green and King 67.4%. In men, the England and Fraser and our new formula 1 had the highest Youden' index 84.7% and 84.1%, respectively. In women, the England and Fraser and RDW index had the highe...Continue Reading

References

Mar 26, 1977·Lancet·I Shine, S Lal
Apr 14, 1973·Lancet·P C Srivastava, J M Bevington
Nov 8, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Aysin DemirAbdurrahman Kara
Mar 17, 2007·Hematology·Cengìz BeyanAlì Ihsan Uzar
May 4, 2007·Annals of Hematology·George NtaiosStiliani Alexiou-Daniel
Jul 12, 2007·Annals of Hematology·Cengiz BeyanAhmet Ifran
Feb 21, 2008·American Journal of Clinical Pathology·Alexandra M HarringtonSteven H Kroft
Jul 16, 2008·Journal of Postgraduate Medicine·D Aslan
Dec 6, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Eloísa Urrechaga
Jul 8, 2009·Pakistan Journal of Biological Sciences : PJBS·M A EhsaniA Rashidi

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Citations

Jun 13, 2020·Scandinavian Journal of Clinical and Laboratory Investigation·Johannes J M L Hoffmann, Eloísa Urrechaga

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