PMID: 15235323Jul 6, 2004Paper

Introduction-preventing insulin resistance through exercise: a cellular approach

Medicine and Science in Sports and Exercise
John A Hawley, Joseph A Houmard

Abstract

Insulin resistance is a progressive metabolic disorder associated with inactivity, ageing, genetic predisposition and environmental factors, and is a hallmark feature of a variety of disease states including obesity, dyslipidemia, hypertension, polycystic ovarian syndrome, arteriosclerosis and noninsulin dependent (Type 2) diabetes mellitus. The primary defect in the development of whole body insulin resistance remains unclear. However, during the past decade major advances have been made in our understanding of the molecular and cellular mechanisms regulating the entry of glucose into insulin-sensitive tissues. Such an understanding is critical in the identification of specific glucoregulatory biochemical/molecular sites that can be targeted by treatment strategies (i.e. exercise training) in the prevention and treatment of insulin resistance. The five papers comprising this symposium provide a state-of-the-art synopsis of the metabolic, cellular, and molecular mechanisms positively affected by exercise training in individuals who are insulin resistant.

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Citations

Oct 21, 2011·Revista da Associação Médica Brasileira·Aparecido Pimentel FerreiraOtávio Tolêdo Nóbrega
Jun 24, 2008·Diabetes Research and Clinical Practice·Laila C J LimaHerbert G Simões
Dec 25, 2007·Advances in Chronic Kidney Disease·Irfan Moinuddin, David J Leehey
Jan 4, 2008·Acta Physiologica·J A Hawley, S J Lessard
Oct 30, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Jakob F WefersPaul M Coen
Nov 16, 2018·Aging Cell·Kurt A EscobarTrisha A VanDusseldorp
Apr 3, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John P Thyfault
Oct 2, 2008·American Journal of Physiology. Endocrinology and Metabolism·Boubacar BenzianeNigel K Stepto
Jun 11, 2009·Scandinavian Journal of Medicine & Science in Sports·E SillanpääD E Laaksonen
Oct 24, 2009·Médecine sciences : M/S·Benjamin C Guinhouya

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