Abstract
Allergic diseases result from IgE-mediated immune responses to foreign protein (allergens). The majority of such reactions are IgE-mediated (type I) reactions. Individuals who develop such reactions are allergic. Those predisposed on a genetic basis to synthesize IgE to environmental allergens are atopic. Most allergic reactions are precipitated when a specific allergen aggregates several IgE molecules attached to IgE receptors on the surfaces of mast cells and basophils. Chemical mediators are released which lead to the immediate signs and symptoms associated with allergic diseases including hives, asthma, and anaphylaxis. More prolonged reactions follow if significant numbers of other cells including eosinophils, macrophages, and lymphocytes are drawn into sites of mast cell activation. Therefore, allergic diseases result from a complex interplay of immune cells, foreign proteins, and tissue inflammation.
References
Aug 6, 1992·The New England Journal of Medicine·H A SampsonJ P Rosen
May 7, 1992·Nature·R J ArmitageC R Maliszewski
Aug 1, 1992·The Journal of Allergy and Clinical Immunology·R S Geha
Feb 1, 1991·The Journal of Clinical Investigation·B K WershilS J Galli
May 4, 1989·Nature·M PlautW E Paul
Jan 1, 1989·Annual Review of Immunology·T R Mosmann, R L Coffman
Jun 25, 1987·The New England Journal of Medicine·L B SchwartzT Sullivan
Oct 29, 1987·The New England Journal of Medicine·H D Royer, E L Reinherz
Dec 3, 1987·The New England Journal of Medicine·M D Cooper
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·F Levi-SchafferR L Stevens
Jul 1, 1993·The Journal of Allergy and Clinical Immunology·F L Pearce
Sep 23, 1993·Nature·J F GauchatJ Thompson
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J PunnonenJ E de Vries
Dec 2, 1993·Nature·B J Sutton, H J Gould
Jul 1, 1993·The Journal of Allergy and Clinical Immunology·M A Kaliner
Nov 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·F BOREKP G GELL
Citations
Apr 1, 2000·The British Journal of Nutrition·H S GillP K Gopal
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Steve L Taylor
Mar 27, 2013·BMC Bioinformatics·Jing WangJing Li
Jan 6, 2009·BMC Bioinformatics·Shen Jean LimMartti T Tammi
Dec 5, 2006·Anais Da Academia Brasileira De Ciências·Luiz F L ReisMauro M Teixeira
Jan 30, 2004·The British Journal of Dermatology·K OritoH Matsuda
Nov 22, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J LinM J C Alcocer
May 23, 2002·Annals of the New York Academy of Sciences·Tong-Jen Fu