Introduction to the reviews on neuropeptide Y

Neuropeptides
Donald R Gehlert

Abstract

Neuropeptide Y (NPY) was first reported as an abundant peptide in brain tissue in 1982. Shortly thereafter, NPY was found to be a member of a peptide family consisting of the endocrine peptides pancreatic polypeptide (PP) and peptide YY (PYY). These peptides exert most of their biological effects through five G-protein coupled receptors termed Y1, Y2, Y4, Y5 and y6 that mediate either inhibition adenylate cyclase or increases in intracellular calcium. Since the discovery of NPY, a robust a body of literature has developed around the potential functions of this peptide. While initial findings identified NPY is an important contributor to the regulation of feeding, body weight and blood pressure, more recent work as revealed more subtle functions of this peptide and its potential role in affective disorders, bone formation and cravings. The accompanying twelve reviews detail important developments in our understanding of the functional role of NPY.

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Citations

Feb 9, 2011·Archives of General Psychiatry·Brian J MickeyJon-Kar Zubieta
Nov 14, 2013·Seminars in Liver Disease·Jamie Eugene Mells, Frank A Anania
Jun 11, 2011·Neuropeptides·Katarzyna Kaczyńska, Małgorzata Szereda-Przestaszewska
Oct 23, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·E ZambelloL Caberlotto
Sep 15, 2009·Neuropeptides·Nicola J Lee, Herbert Herzog
Jan 16, 2007·Peptides·Meike Körner, Jean Claude Reubi
Nov 11, 2008·Annals of the New York Academy of Sciences·Rajita Sinha
Jul 14, 2011·Journal of Cellular Biochemistry·Lara BaticicJadranka Varljen
Nov 6, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·I G A KirisM Kumlu
Feb 4, 2012·Bioorganic & Medicinal Chemistry Letters·Naoki OmoriTakayuki Okuno
Jul 6, 2016·Experimental Neurology·Sarah N SchmeltzerRenu Sah
Oct 15, 2011·Expert Opinion on Therapeutic Targets·Gang WuAleksander A Mathé
Apr 5, 2020·Scientific Reports·Kazuhiro ShiozakiAkio Inui
Mar 14, 2019·Frontiers in Neuroscience·Jovana JoksimovicGvozden Rosic
Jan 14, 2017·Frontiers in Aging Neuroscience·Yingying YueYonggui Yuan
Oct 5, 2018·Frontiers in Physiology·Cheryl M J TanNeil Herring
Nov 19, 2019·Neuropeptides·Kanwal IftikharSumbul Zehra
Mar 13, 2021·Frontiers in Endocrinology·Emilio J Vélez, Suraj Unniappan
Aug 29, 2006·Neuropeptides·Sarika Arora, Anubhuti
Jun 30, 2005·Journal of the American Chemical Society·Shaun D Mendonsa, Michael T Bowser
Jun 6, 2008·Journal of the American Chemical Society·Michael HaackAnnette G Beck-Sickinger

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