Introduction to the Special Issue "The Brain-Gut Axis".

Cellular and Molecular Neurobiology
Yvette Taché, Juan M Saavedra


This special Issue presents comprehensive and state-of-the-art advances in supporting the crucial role of the bidirectional interactions between the Brain-Gut Axis in health and diseases with an emphasis on the microbiome-gut-brain axis and its implications in variety of neurological disorders. There are intimate connections between the brain and the digestive system. Gut microbiota dysbiosis activates the intestinal immune system, enhances intestinal permeability and bacterial translocation, leading to neuroinflammation, epigenetic changes, cerebrovascular alterations, amyloid β formation and α-synuclein protein aggregates. These alterations may participate in the development of hypertension, Alzheimer, Parkinson, stroke, epilepsy and autism. Brainstem nuclei such as the nucleus tractus solitarius (NTS) and the dorsal motor nucleus of the vagus (DMV) regulate gastric motor function by way of bidirectional inputs through the vagus nerve.


Aug 17, 2018·Neurochemistry International·Lindsay Joy SpielmanAndis Klegeris
Oct 9, 2020·Cellular and Molecular Neurobiology·Olga A LyubashinaSergey S Panteleev
Nov 26, 2020·Cellular and Molecular Neurobiology·Pablo IruzubietaConcepción Junquera
Jan 6, 2021·Cellular and Molecular Neurobiology·Manuel H JaneiroMaite Solas
Feb 18, 2021·Cellular and Molecular Neurobiology·Christopher L SoudersChristopher J Martyniuk
Feb 27, 2021·Cellular and Molecular Neurobiology·Linna ZhaoShixin Xu
Mar 3, 2021·Cellular and Molecular Neurobiology·Nitu DograDeepshikha Pande Katare
Apr 5, 2021·Cellular and Molecular Neurobiology·Richard A GillisNiaz Sahibzada
Jun 1, 2021·Cellular and Molecular Neurobiology·Gerald A HigginsJohn W Wiley
Jul 20, 2021·Cellular and Molecular Neurobiology·Qiang YueChang Zeng

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