Introduction to Thiopeptides: Biological Activity, Biosynthesis, and Strategies for Functional Reprogramming.

Cell Chemical Biology
Alexander A Vinogradov, Hiroaki Suga

Abstract

Thiopeptides (also known as thiazolyl peptides) are structurally complex natural products with rich biological activities. Known for over 70 years for potent killing of Gram-positive bacteria, thiopeptides are experiencing a resurgence of interest in the last decade, primarily brought about by the genomic revolution of the 21st century. Every area of thiopeptide research-from elucidating their biological function and biosynthesis to expanding their structural diversity through genome mining-has made great strides in recent years. These advances lay the foundation for and inspire novel strategies for thiopeptide engineering. Accordingly, a number of diverse approaches are being actively pursued in the hope of developing the next generation of natural-product-inspired therapeutics. Here, we review the contemporary understanding of thiopeptide biological activities, biosynthetic pathways, and approaches to structural and functional reprogramming, with a special focus on the latter.

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Citations

Jul 7, 2021·FEMS Microbiology Reviews·Abdelahhad BarbourMichael Glogauer
Nov 20, 2020·Journal of the American Chemical Society·Alexander A VinogradovHiroaki Suga
Aug 17, 2021·Journal of the American Chemical Society·Alexander A VinogradovHiroaki Suga
Aug 28, 2020·Organic Letters·Graham A HudsonDouglas A Mitchell

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