Introduction: What we do and do not know regarding redox processes of thiols in signaling pathways

Free Radical Biology & Medicine
Leslie B Poole, Christian Schöneich

Abstract

Due to their susceptibility towards redox modification, protein thiols represent primary targets for the modulation of protein activity, conformation and oligomerization. Until fairly recently, such modifications were considered "damage" as a result of oxidative stress, before researchers recognized their physiological importance for biologic signaling. This paradigm shift, and the associated necessity to accurately characterize and quantify the various pathways of thiol redox modifications not only for specific proteins, but also within the cellular environment, has enticed researchers to take a close look at the impact of environment and molecular (protein) structure on these reactions. This Special Issue on Redox Biology of Thiols in Signaling Pathways is the result of a workshop organized at the 2013 Annual Meeting of the Society for Free Radical Biology and Medicine in San Antonio, Texas, summarizing the contributions from many of the presenters. It will provide a stimulating synopsis on what is known, and what is not known, about the reaction mechanisms which underlie the role of thiols and oxidative processes in signaling pathways.

References

Feb 22, 2003·The Journal of Biological Chemistry·David Jourd'heuilMartin Feelisch
Feb 9, 2010·Antioxidants & Redox Signaling·Vamsi K Kodali, Colin Thorpe
Mar 1, 2012·The Biochemical Journal·Ashlee HigdonVictor M Darley-Usmar
Jun 5, 2012·Antioxidants & Redox Signaling·Lauren MitchellSharon L Campbell
Nov 21, 2012·ACS Chemical Biology·Nicholas J Pace, Eranthie Weerapana
Sep 28, 2014·Free Radical Biology & Medicine·Nelmi O Devarie BaezCristina M Furdui
Oct 4, 2014·Free Radical Biology & Medicine·Christine C Winterbourn
Nov 30, 2014·Free Radical Biology & Medicine·Leslie B Poole
Dec 3, 2014·Free Radical Biology & Medicine·P Andrew Karplus
Dec 17, 2014·Free Radical Biology & Medicine·Thomas NauserChristian Schöneich

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Citations

Jun 22, 2018·Journal of Integrative Bioinformatics·Alexandre MaesMarc Baaden
Dec 1, 2018·Antioxidants & Redox Signaling·Mirko ZaffagniniPaolo Trost
Jul 28, 2018·Oxidative Medicine and Cellular Longevity·Alessandro Giuffrè, João B Vicente
Jul 28, 2018·Scientific Reports·Hussam J Al-BarakatiDukka B Kc
Jan 6, 2019·Journal of Biomedical Science·Yu-Ling TsaiHsin-Chih Lai
Feb 19, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paul K Witting
Sep 3, 2021·Biochimica Et Biophysica Acta. General Subjects·Pablo ArmasNora B Calcaterra
Oct 2, 2021·Diabetes·Barbara E CorkeyMatthew J Merrins

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