Intron F G79A polymorphism of the protein Z gene in Turkish Behçet patients

Current Eye Research
Helin Deniz DemirNejat Akar

Abstract

Vasculitis is one of the major findings of Behçet's disease (BD). Protein Z (PZ) is a glycoprotein that acts as a cofactor of PZ-dependent protease inhibitor and suppresses trombus formation by inhibiting activated factor Xa. Polymorphism of the PZ gene was mentioned as a genetic risk factor for various thrombotic events. The aim of this study is to investigate the intron F G79A polymorphism of the PZ gene in Behçet patients with and without ocular involvement. Seventy-six patients and 70 controls were included in the study. Intron F G79A polymorphism of PZ gene was determined by polymerase chain reaction based DNA analysis. The frequency of A allele and the distribution of genotypes were assessed by χ(2) test and the genotype distribution and Hardy-Weinberg equilibrium were tested with the χ(2) test for quality of fit. The frequency of the A allele was significantly higher in overall Behçet patients than in controls (odds ratio [OR] = 6.8; 95% CI, 2.6 to 17.9; p = 0.0001). It was also significantly higher in patients with (OR = 5.3; 95% CI, 1.83 to 15.6; p = 0.0024) or without (OR = 8.2; 95% CI, 2.95 to 22.5; p = 0.0001) ocular involvement compared to controls. However, A allele frequency was not significantly different betwee...Continue Reading

References

Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z F YinG J Broze
Apr 18, 2002·Thrombosis Research·Sedat KirazMeral Calgüneri
Sep 26, 2002·Thrombosis Research·Bettina Kemkes-MatthesKarl J Matthes
Sep 26, 2003·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·M Akif OztürkIbrahim C Haznedaroglu
Jun 29, 2004·Journal of Thrombosis and Haemostasis : JTH·R SantacroceM Margaglione
May 10, 2005·Stroke; a Journal of Cerebral Circulation·J StatonJ W Eikelboom
Aug 30, 2006·Journal of Thrombosis and Haemostasis : JTH·R SantacroceM Margaglione
Feb 5, 2008·Journal of Thrombosis and Thrombolysis·Aydan ErogluNejat Akar

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Citations

Jun 28, 2016·Pharmacogenomics·Tamer A GheitaSanaa A Kenawy
Jan 14, 2016·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Sherif M YousryRasha M El Refai

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