PMID: 8943030Nov 26, 1996Paper

Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can function as an enhancer element in Drosophila

Proceedings of the National Academy of Sciences of the United States of America
T E Haerry, W J Gehring

Abstract

The 5' flanking sequences and the intron of the mouse Hoxa-7 gene were searched for regulatory elements that can function in Drosophila. Only the intron is able to activate a lacZ fusion gene in various tissues of Drosophila embryos. This enhancer function requires a cluster of three homeodomain binding sites (HB1-element) that are also found in the introns of other Hox genes as well as in a putative autoregulatory element of Ultrabithorax (Ubx), the Drosophila homolog of Hoxa-7. If a single binding site in the autoregulatory element of fushi tarazu (ftz) is replaced by the HB1-element of Hoxa-7, the expression pattern is altered and newly controlled by the homeotic gene caudal (cad). These data suggest that HB1 is a potential target for different homeodomain proteins of both vertebrates and invertebrates.

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Citations

Jan 23, 1998·The Journal of Experimental Zoology·J L CarrF H Ruddle
Aug 26, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T PapenbrockA Awgulewitsch
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Mar 29, 2020·BMC Infectious Diseases·Peifeng LiangZhongqin Guo
Mar 15, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hui ZhangJun Ren

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