PMID: 8949805Sep 1, 1996Paper

Intubating conditions and time course of rocuronium-induced neuromuscular block in children

British Journal of Anaesthesia
T Fuchs-Buder, E Tassonyi

Abstract

We have investigated the potential of rocuronium 0.6 mg kg-1 (2xED95) and 0.9 mg kg-1 (3xED95) for rapid sequence induction in 100 children, aged 3-7 yr. Intubating conditions with the two different doses of rocuronium were assessed in 70 children (n = 35 in each group) undergoing elective surgery. Intubation was carried out by mimicking rapid sequence induction, and intubation conditions were evaluated according to a standard score. Intubating conditions were good to excellent in all 70 patients investigated (2xED95: excellent 29, good 6; 3xED95: excellent 33, good 2). In another 30 children (n = 15 in each group), we examined the times of rocuronium-induced neuromuscular block using electromyography. Lag time and recovery index did not differ significantly between the two groups (lag time: 37 (SD 12) vs 33 (14) s; recovery index: 9 (3) vs 10 (4) min). Three times the ED95 induced deeper neuromuscular block, 1 min after injection compared with 2xED95 (twitch height: 42 (24) vs 25 (19)%, respectively; P < 0.05). The same was true for onset time (193 (47) vs 118 (23) s; P < 0.01), clinical duration (21 (4) vs 34 (11) min; P < 0.01) and duration to 75% recovery (30 (6) vs 44 (4) min; P < 0.01). By mimicking rapid sequence inducti...Continue Reading

Citations

Jul 3, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Matthias BockJohann Motsch
Aug 1, 1996·Journal of Clinical Anesthesia·B A Liang, C J Coté
Nov 26, 1999·Archives of Medical Research·F Villegas-SánchezE Y Velázquez-Armenta
Nov 5, 1997·Journal of Clinical Anesthesia·E SimhiS K Woelfel
Nov 7, 2001·Paediatric Anaesthesia·G H Meakin
Mar 8, 2002·Paediatric Anaesthesia·Claudia A Y ChengTony Gin
Feb 21, 2003·British Journal of Anaesthesia·M PellégriniE Tassonyi
Jan 4, 2001·Pediatric Emergency Care·K A Doobinin, T A Nakagawa
May 5, 2007·Current Opinion in Anaesthesiology·George H Meakin
Apr 14, 2004·Paediatric Anaesthesia·H-J RappC Waschke
Mar 4, 2008·Paediatric Anaesthesia·Seung-Hoon BaekSang-Wook Shin
Jan 11, 2000·Emergency Medicine Clinics of North America·P S Wadbrook
May 26, 2010·Korean journal of anesthesiology·Sang Kyu LeeAe Ra Kim
Feb 22, 2017·European Journal of Anaesthesiology·Florence Julien-MarsollierSouhayl Dahmani
Mar 17, 2009·Pediatric Emergency Care·Kevin Y Ching, Carl R Baum
May 16, 2000·Anesthesia and Analgesia·Barbara W Brandom
Sep 19, 2019·Acta Anaesthesiologica Scandinavica·Flora T ScheffenbichlerMatthias Eikermann
Oct 1, 2013·European Journal of Anaesthesiology·Thomas Fuchs-Buder, Denis Schmartz
May 16, 2000·Anesthesia and Analgesia·D Ryan Cook

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