Inulin fiber dose-dependently modulates energy balance, glucose tolerance, gut microbiota, hormones and diet preference in high-fat-fed male rats

The Journal of Nutritional Biochemistry
Arashdeep SinghPrasanth K Chelikani

Abstract

Inulin, a popular prebiotic fiber, has been reported to promote satiety and fat loss; however, the dose-response effects of inulin on energy balance and diet preference, and whether the metabolic effects are independent of calorie restriction are not well characterized. Therefore, we compared the effects of diets varying in inulin concentrations on food intake, energy expenditure, body composition, gut microbiota and hormones, and assessed whether inulin-induced hypophagia was due to reduced diet preference. In experiment 1, male rats were randomized to six high-fat diet groups: control (CON, 0% inulin), 2.5% inulin (2.5IN), 10% inulin (10IN), 25% inulin (25IN), 25% cellulose (25CE) or pair-fed to 25IN (25PF) for 21 days. We demonstrate that inulin dose-dependently decreased caloric intake and respiratory quotient; improved glucose tolerance; increased the abundance of Bacteroidetes and Bifidobacterium spp.; decreased Clostridium clusters I and IV; increased butyryl-CoA:acetate CoA-transferase in cecum; upregulated peptide YY, cholecystokinin and proglucagon transcripts in the cecum and colon; and increased plasma peptide YY and glucagon-like peptide-1 concentrations. Importantly, unlike 25PF, 25IN attenuated the reduction in e...Continue Reading

Citations

Aug 1, 2019·Molecular Nutrition & Food Research·Rizaldy C ZapataPrasanth K Chelikani
Oct 9, 2019·Nutrients·Emanuele RinninellaMaria Cristina Mele
Mar 2, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Arashdeep SinghPrasanth K Chelikani
Sep 29, 2018·Current Nutrition Reports·Edward S ChambersDouglas J Morrison
Oct 21, 2018·Medical Sciences : Open Access Journal·Yurdagül ZopfWalburga Dieterich
Dec 17, 2018·Applied Microbiology and Biotechnology·Fernanda BianchiKatia Sivieri
Feb 13, 2020·Cell Reports·Yan LiZe'ev A Ronai
Jul 25, 2021·International Journal of Molecular Sciences·Haruki UsudaKoichiro Wada
Oct 27, 2021·Critical Reviews in Food Science and Nutrition·Min ZhouXi Ma

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