Invariant natural killer T cells contribute to the allergic response in cow's milk protein-sensitized mice

International Archives of Allergy and Immunology
B SchoutenJ Garssen

Abstract

Little is known about the contribution of the invariant natural killer T (iNKT) cells in the onset of food allergy. Using a mouse model for cow's milk allergy the function of iNKT cells was investigated. Mice were sensitized orally with casein or whey proteins. One hour before the sensitizations the mice were injected intraperitoneally with α-galactosylceramide (αGalCer) or control. One week after the last sensitization acute allergic skin reactions were measured. Furthermore, in the liver, spleen and mesenteric lymph nodes (MLN) percentages of iNKT cells were analyzed and liver lymphocyte restimulation assays were performed. Whey- or casein-sensitized mice treated with αGalCer showed enhanced acute allergic skin reactions. The percentage of iNKT cells in the liver of sensitized mice was reduced compared to sham-sensitized mice. αGalCer treatment was found to deplete iNKT cells in the liver of sensitized as well as sham-sensitized mice, and these hepatocytes did not respond to ex vivo restimulation with αGalCer. αGalCer treatment did not reduce iNKT cell percentages in the spleen and MLN of sham-sensitized mice but abrogated the increase in iNKT cell percentage in the spleen upon whey sensitization, whereas it enhanced the iNKT...Continue Reading

References

Nov 3, 2001·The Journal of Allergy and Clinical Immunology·H L RhodesJ J Cogswell
Mar 6, 2002·The Journal of Experimental Medicine·Jenny E GumperzMichael B Brenner
Jun 18, 2002·Nature Medicine·Frank A RedegeldFrans P Nijkamp
Aug 3, 2002·Nature Reviews. Immunology·Mitchell Kronenberg, Laurent Gapin
Oct 9, 2002·The Journal of Nutrition·Martial DanginBernard Beaufrère
Dec 19, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Arne Høst
Dec 19, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Sami L Bahna
Apr 2, 2003·Nature Reviews. Immunology·Allan McI Mowat
Apr 17, 2003·Trends in Immunology·Frank A Redegeld, Frans P Nijkamp
Mar 25, 2004·Nature Reviews. Immunology·Dale I GodfreyLuc Van Kaer
Dec 4, 2004·The Journal of Allergy and Clinical Immunology·Jae-Ouk KimChang-Yuil Kang
Apr 2, 2005·American Journal of Respiratory Cell and Molecular Biology·Hiroyuki MatsudaHirotoshi Nakamura
Sep 3, 2005·The Journal of Clinical Investigation·Barbara A Sullivan, Mitchell Kronenberg
Sep 3, 2005·The Journal of Clinical Investigation·Vrajesh V ParekhLuc Van Kaer
Sep 24, 2005·European Journal of Immunology·Patricia HachemMaria C Leite-de-Moraes
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philip W AskenaseMarian Szczepanik
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Everett H MeyerDale T Umetsu
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Randy R Brutkiewicz
Apr 25, 2007·International Reviews of Immunology·Terry L Delovitch
Apr 25, 2007·International Reviews of Immunology·Michael Nowak, Joan Stein-Streilein
Aug 25, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sebastian ZeissigRichard S Blumberg
Sep 11, 2007·Trends in Immunology·Victoria S StrongeVincenzo Cerundolo
Mar 21, 2008·Trends in Pharmacological Sciences·Marco ThioFrank A Redegeld
Jun 4, 2008·International Archives of Allergy and Immunology·Bastiaan SchoutenJohan Garssen
Oct 7, 2008·Trends in Immunology·Noriko M Tsuji, Akemi Kosaka
Oct 14, 2008·Current Opinion in Immunology·Justin M Skripak, Hugh A Sampson
Nov 18, 2008·Cellular Immunology·Megumi GotoTakashi Nishimura
Dec 2, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T Groot KormelinkF A Redegeld
Dec 23, 2008·Immunology Letters·Verena Niederberger
Feb 4, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A SchroederX Wang
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hye Young KimDale T Umetsu
Apr 24, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B C A M van EschF A Redegeld
May 4, 2010·The Journal of Allergy and Clinical Immunology·Bastiaan SchoutenJohan Garssen

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Citations

Jul 9, 2014·Mediators of Inflammation·Juandy JoElena Sandalova
Dec 22, 2017·NPJ Vaccines·Danuta Gutowska-Owsiak, Graham S Ogg

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