Invariant natural killer T cells from rhesus macaque spleen and peripheral blood are phenotypically and functionally distinct populations

Journal of Medical Primatology
B GansuvdJ M Thomas

Abstract

Natural killer T cells (NKT) possess dual functions of innate and adaptive immune systems, controlling viral infections and regulating autoimmune diseases. Non-human primates (NHP) are penultimate models for advancing therapeutic immunoregulatory strategies for translational application in humans, though, little is known about NHP NKT cells. Here we characterized rhesus macaque NKT cells ex vivo. The frequency, phenotype and intracellular cytokine production of V alpha 24+ 6B11+ invariant NKT (iNKT) cells were analyzed by multi-color flow cytometry. V alpha 24J alpha Q mRNA expression was analyzed by real-time RT-PCR. The frequencies of peripheral blood (PB) and spleen V alpha 24+ 6B11+ iNKT cells were not significantly different. The iNKT cell subset in spleen was significantly increased for CD4+ CD8+ and CD3+ CD56+ co-expression as well as intracellular interleukin-4 production, which was rarely observed in circulating PB. Spleen iNKT cells in rhesus macaques are Th2 biased and display phenotypically and functionally distinct profiles from their PB counterpart.

References

May 1, 1981·The Journal of Experimental Medicine·J W Streilein, J Y Niederkorn
Sep 1, 1994·Clinical and Experimental Immunology·Y TakiiT Abo
Mar 15, 1996·Cellular Immunology·A SummerfieldA Saalmüller
Aug 1, 1996·Journal of Virology·G A DeanN C Pedersen
Jan 1, 1997·Annual Review of Immunology·A BendelacJ H Roark
Jul 7, 1997·The Journal of Experimental Medicine·M ExleyS Porcelli
Jun 25, 1998·Developmental and Comparative Immunology·K H NamY Yoshikawa
Aug 26, 1998·Clinical and Experimental Immunology·N MushaT Abo
Apr 6, 1999·The Journal of Experimental Medicine·D ZengS Strober
Dec 30, 1999·Veterinary Immunology and Immunopathology·F A Zuckermann
Feb 24, 2000·The Journal of Experimental Medicine·M J SmythD I Godfrey
Nov 30, 2000·Immunology Today·D I GodfreyA G Baxter
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D E FaunceJ Stein-Streilein
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·K I SeinoK Okumura
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S M TahirM A Exley
Mar 6, 2002·The Journal of Experimental Medicine·Jenny E GumperzMichael B Brenner
Mar 6, 2002·The Journal of Experimental Medicine·Peter T LeeAlbert Bendelac
Aug 3, 2002·Nature Immunology·Shin-ichiro FujiiRalph M Steinman
Aug 3, 2002·Nature Reviews. Immunology·Mitchell Kronenberg, Laurent Gapin
Jan 25, 2003·Parasitology International·Hisami WatanabeToru Abo
Feb 20, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lekidelu Taddesse-HeathElaine S Jaffe
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Balgansuren GansuvdJudith M Thomas
Nov 11, 2003·Clinical and Diagnostic Laboratory Immunology·Kamal U SaikhRobert G Ulrich
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yang YangJi-Won Yoon
Jan 9, 2004·International Journal for Parasitology·Diana S Hansen, Louis Schofield
Feb 12, 2004·Cancer Research·Howard J WajchmanKenneth E Dombrowski
Sep 11, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Ken-ichiro Seino, Masaru Taniguchi
Nov 13, 2004·Science·Dapeng ZhouAlbert Bendelac

❮ Previous
Next ❯

Citations

Dec 5, 2008·Journal of Virology·Caroline S FernandezStephen J Kent
Oct 31, 2012·PloS One·Xiangming LiMoriya Tsuji
Jun 11, 2008·Immunology and Cell Biology·Anneliese O SpeakFrances M Platt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.