PMID: 8605732Mar 1, 1996Paper

Invasion-inhibiting factor 2-albumin conjugate inhibits invasion and spontaneous metastasis of MKL-4 human breast cancer cells transplanted into female nude mice

Clinical & Experimental Metastasis
J KurebayashiH Sonoo

Abstract

Invasion-inhibiting factor 2 (IIF-2) and its albumin conjugate have been reported to inhibit spontaneous metastasis of highly metastatic cancer cells with no effect on primary tumor growth. To confirm the inhibitory effects of the IIF-2 conjugate on tumor invasion and spontaneous metastasis, we administered the conjugate intra-peritoneally (i.p.) to female nude mice bearing transplanted tumors with MKL-4 cells, which are MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and lacZ. Neither 10 nor 20 mg/kg doses of the conjugate caused any inhibition of primary tumor growth, but 20 mg/kg significantly inhibited tumor invasion and spontaneous metastasis. Tumor invasion was measured by a novel computer-assisted image analysis. Spontaneous microscopic metastases into lymph nodes and distant organs were measured by whole organ staining for beta-galactosidase activity and observed with a dissecting microscope. The dose of 10 mg/kg significantly inhibited tumor invasion but not metastasis. Interestingly, the number of factor VIII-positive microvessels in the tumors was not reduced by treatment at either dose level. These findings suggest that the anti-invasive effect of the IIF-2 conjugate may reduce both lym...Continue Reading

References

Jun 1, 1990·Biochimica Et Biophysica Acta·C H Blood, B R Zetter
Jan 21, 1992·International Journal of Cancer. Journal International Du Cancer·J Smolle, I A Grimstad
Sep 1, 1990·Japanese Journal of Cancer Research : Gann·A IsoaiH Kumagai
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Apr 15, 1993·Biochemical and Biophysical Research Communications·A IsoaiH Kumagai

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