Invasion inhibition in pancreatic cancer using the oral iron chelating agent deferasirox

BMC Cancer
Shogo AmanoIsao Sakaida

Abstract

Iron is required for cellular metabolism, and rapidly proliferating cancer cells require more of this essential nutrient. Therefore, iron regulation may well represent a new avenue for cancer therapy. We have reported, through in vitro and in vivo research involving pancreatic cancer cell lines, that the internal-use, next-generation iron chelator deferasirox (DFX) exhibits concentration-dependent tumour-suppressive effects, among other effects. After performing a microarray analysis on the tumour grafts used in that research, we found that DFX may be able to suppress the cellular movement pathways of pancreatic cancer cells. In this study, we conducted in vitro analyses to evaluate the effects of DFX on the invasive and migratory abilities of pancreatic cancer cells. We used pancreatic cancer cell lines (BxPC-3, Panc-1, and HPAF II) to examine the efficacy of DFX in preventing invasion in vitro, evaluated using scratch assays and Boyden chamber assays. In an effort to understand the mechanism of action whereby DFX suppresses tumour invasion and migration, we performed G-LISA to examine the activation of Cdc42 and Rac1 which are known for their involvement in cellular movement pathways. In our scratch assays, we observed that D...Continue Reading

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Citations

Sep 16, 2020·Cancer Research·Suzy V Torti, Frank M Torti
Jan 28, 2021·Micromachines·Liu-Yuan GuanBo Li
Feb 26, 2021·Oxidative Medicine and Cellular Longevity·Lesang ShenJian Huang
Nov 7, 2020·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Seyed Mojtaba Mashmoul MoghadamMohammad Ramezani
Jul 16, 2021·Oncotarget·Maura ArgenzianoFrancesca Rossi

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Methods Mentioned

BETA
Assay
GTPase
nucleotide exchange

Software Mentioned

JMP13

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