Abstract
Iron is required for cellular metabolism, and rapidly proliferating cancer cells require more of this essential nutrient. Therefore, iron regulation may well represent a new avenue for cancer therapy. We have reported, through in vitro and in vivo research involving pancreatic cancer cell lines, that the internal-use, next-generation iron chelator deferasirox (DFX) exhibits concentration-dependent tumour-suppressive effects, among other effects. After performing a microarray analysis on the tumour grafts used in that research, we found that DFX may be able to suppress the cellular movement pathways of pancreatic cancer cells. In this study, we conducted in vitro analyses to evaluate the effects of DFX on the invasive and migratory abilities of pancreatic cancer cells. We used pancreatic cancer cell lines (BxPC-3, Panc-1, and HPAF II) to examine the efficacy of DFX in preventing invasion in vitro, evaluated using scratch assays and Boyden chamber assays. In an effort to understand the mechanism of action whereby DFX suppresses tumour invasion and migration, we performed G-LISA to examine the activation of Cdc42 and Rac1 which are known for their involvement in cellular movement pathways. In our scratch assays, we observed that D...Continue Reading
References
Jul 1, 1986·Hematological Oncology·G J KontoghiorghesA V Hoffbrand
Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H A BurrisD D Von Hoff
Dec 31, 2005·Pharmacological Reviews·Danuta S Kalinowski, Des R Richardson
Mar 21, 2009·Cancer Science·Junko H OhyashikiKazuma Ohyashiki
Apr 26, 2011·Cellular Signalling·Kristy Stengel, Yi Zheng
May 13, 2011·The New England Journal of Medicine·Thierry ConroyUNKNOWN PRODIGE Intergroup
Aug 13, 2011·The New England Journal of Medicine·Takahiro YamasakiIsao Sakaida
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel D Von HoffManuel Hidalgo
Mar 29, 2012·The Journal of Biological Chemistry·Zhiqiang ChenDes R Richardson
Apr 13, 2012·Breast Cancer Research : BCR·Ying YanKenneth H Cowan
Oct 18, 2012·Molecular Pharmacology·Goldie Y L LuiDes R Richardson
Nov 7, 2012·British Journal of Pharmacology·S J FordC Tselepis
Nov 29, 2012·Molecular Pharmacology·Jing SunDes R Richardson
Apr 19, 2013·Nature Reviews. Cancer·Suzy V Torti, Frank M Torti
Oct 27, 2014·Oncotarget·Ying YanMichel M Ouellette
Feb 3, 2016·Lancet·Terumi KamisawaKyoichi Takaori
Jun 4, 2016·Journal of Clinical Biochemistry and Nutrition·Naoki YamamotoIsao Sakaida
Jun 15, 2016·British Journal of Cancer·J S AnkenyJ S Tomlinson
Aug 9, 2016·International Journal of Oncology·Seishi NishitaniToshiyoshi Fujiwara
Sep 2, 2016·BMC Cancer·Hirofumi HarimaIsao Sakaida
Nov 12, 2016·World Journal of Gastroenterology : WJG·Issei SaekiIsao Sakaida
Feb 10, 2017·Digestive Diseases and Sciences·Dejun YangRonglin Yan
Apr 30, 2017·Molecular Cancer Therapeutics·Tessa Humphries-BickleySuranganie Dharmawardhane
Aug 16, 2017·Cancer Research·Marcelo G Kazanietz, Maria J Caloca
Sep 22, 2017·International Journal of Molecular Sciences·Stefan Heinrich, Hauke Lang
Dec 12, 2017·Annals of Surgery·Theodoros MichelakosCristina R Ferrone
Jun 3, 2018·Cancer Research·María Del Mar Maldonado, Suranganie Dharmawardhane
Jul 10, 2018·Oncotarget·Shuhei ShinodaIsao Sakaida
Mar 15, 2019·Annals of Surgical Oncology·Yoshihiro MiyasakaMasafumi Nakamura
Citations
Sep 16, 2020·Cancer Research·Suzy V Torti, Frank M Torti
Jan 28, 2021·Micromachines·Liu-Yuan GuanBo Li
Feb 26, 2021·Oxidative Medicine and Cellular Longevity·Lesang ShenJian Huang
Nov 7, 2020·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Seyed Mojtaba Mashmoul MoghadamMohammad Ramezani
Jul 16, 2021·Oncotarget·Maura ArgenzianoFrancesca Rossi