Invasion of Africa by a single pfcrt allele of South East Asian type.

Malaria Journal
Frédéric ArieyOdile Mercereau-Puijalon

Abstract

Because of its dramatic public health impact, Plasmodium falciparum resistance to chloroquine (CQ) has been documented early on. Chloroquine-resistance (CQR) emerged in the late 1950's independently in South East Asia and South America and progressively spread over all malaria areas. CQR was reported in East Africa in the 1970's, and has since invaded the African continent. Many questions remain about the actual selection and spreading process of CQR parasites, and about the evolution of the ancestral mutant gene(s) during spreading. Eleven clinical isolates of P. falciparum from Cambodia and 238 from Africa (Senegal, Ivory Coast, Bukina Faso, Mali, Guinea, Togo, Benin, Niger, Congo, Madagascar, Comoros Islands, Tanzania, Kenya, Mozambique, Cameroun, Gabon) were collected during active case detection surveys carried out between 1996 and 2001. Parasite DNA was extracted from frozen blood aliquots and amplification of the gene pfcrt exon 2 (codon 72-76), exon 4 and intron 4 (codon 220 and microsatellite marker) were performed. All fragments were sequenced. 124 isolates with a sensitive (c76/c220:CVMNK/A) haplotype and 125 isolates with a resistant c76/c220:CVIET/S haplotype were found. The microsatellite showed 17 different types...Continue Reading

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Citations

Jul 29, 2010·The Journal of Infectious Diseases·Miriam K LauferChristopher V Plowe
Mar 2, 2013·The Journal of Infectious Diseases·Tatiana M Lopera-MesaRick M Fairhurst
Dec 31, 2011·The Journal of Antimicrobial Chemotherapy·Vanshika LumbYagya D Sharma
Mar 24, 2010·Antimicrobial Agents and Chemotherapy·Valérie AndriantsoanirinaDidier Ménard
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Dec 19, 2007·Malaria Journal·Marie-Thérèse EkalaOdile Mercereau-Puijalon
Dec 16, 2009·Malaria Journal·Harold Townson
Apr 3, 2010·PLoS Pathogens·Sumiti VinayakVenkatachalam Udhayakumar
Jan 10, 2014·Memórias do Instituto Oswaldo Cruz·Gauri Awasthi, Aparup Das
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Sep 3, 2014·The Journal of Infectious Diseases·Carol Hopkins Sibley
Feb 9, 2012·Memórias do Instituto Oswaldo Cruz·Gauri AwasthiAparup Das
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Datasets Mentioned

BETA
AF030694

Methods Mentioned

BETA
PCR
electrophoresis

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