Invasion of mosquito salivary glands by malaria parasites: prerequisites and defense strategies.

International Journal for Parasitology
Ann-Kristin MuellerKristin Michel

Abstract

The interplay between vector and pathogen is essential for vector-borne disease transmission. Dissecting the molecular basis of refractoriness of some vectors may pave the way to novel disease control mechanisms. A pathogen often needs to overcome several physical barriers, such as the peritrophic matrix, midgut epithelium and salivary glands. Additionally, the arthropod vector elicites immune responses that can severely limit transmission success. One important step in the transmission of most vector-borne diseases is the entry of the disease agent into the salivary glands of its arthropod vector. The salivary glands of blood-feeding arthropods produce a complex mixture of molecules that facilitate blood feeding by inhibition of the host haemostasis, inflammation and immune reactions. Pathogen entry into salivary glands is a receptor-mediated process, which requires molecules on the surface of the pathogen and salivary gland. In most cases, the nature of these molecules remains unknown. Recent advances in our understanding of malaria parasite entry into mosquito salivary glands strongly suggests that specific carbohydrate molecules on the salivary gland surface function as docking receptors for malaria parasites.

References

Jan 1, 1991·Comparative Biochemistry and Physiology. A, Comparative Physiology·J M RibeiroR Endris
Oct 1, 1990·Medical and Veterinary Entomology·D H MolyneuxM Kamhawi
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M HuberL H Miller
Apr 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C F GolendaR A Wirtz
Jan 1, 1988·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·S J OntellT E Starzl
Nov 1, 1994·The Journal of Eukaryotic Microbiology·P F PimentaL Miller
Jul 1, 1994·The Journal of Experimental Medicine·P SinnisV Nussenzweig
Aug 15, 1994·Annals of the New York Academy of Sciences·K A JoinerJ F Dubremetz
Nov 24, 1999·The EMBO Journal·J T DessensR E Sinden
Mar 23, 2000·Insect Biochemistry and Molecular Biology·J M RibeiroR Charlab
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·J D BrennanN Kumar
Nov 1, 2001·Proceedings of the National Academy of Sciences of the United States of America·A K GhoshM Jacobs-Lorena
May 22, 2002·The Journal of Experimental Medicine·Tohru KariuYasuo Chinzei
Aug 15, 2002·The Journal of Biological Chemistry·Kai MatuschewskiStefan H I Kappe
Sep 6, 2002·Insect Biochemistry and Molecular Biology·J G ValenzuelaJ M C Ribeiro
Sep 13, 2002·Insect Biochemistry and Molecular Biology·Yeon Soo Han, Carolina Barillas-Mury
Jun 27, 2003·Insect Biochemistry and Molecular Biology·Jesus G ValenzuelaJosé M C Ribeiro
Nov 25, 2003·The Journal of Biological Chemistry·Eappen G AbrahamMarcelo Jacobs-Lorena
Dec 12, 2003·Molecular and Biochemical Parasitology·Joon Mo MyungPhotini Sinnis
Jan 20, 2004·Insect Molecular Biology·E CalvoO Marinotti
Feb 24, 2004·Insect Biochemistry and Molecular Biology·J M C RibeiroJ G Valenzuela
Mar 9, 2004·Molecular and Biochemical Parasitology·Joanne ThompsonAndrew P Waters
May 19, 2004·Insect Biochemistry and Molecular Biology·José M C RibeiroJesus G Valenzuela
Jun 10, 2004·Cellular Microbiology·Dina VlachouFotis C Kafatos
Jun 10, 2004·Cellular Microbiology·Friedrich FrischknechtRobert Ménard
Jul 10, 2004·Insect Biochemistry and Molecular Biology·Mario H Rodriguez, Fidel de la C Hernández-Hernández
Sep 29, 2004·Trends in Cell Biology·Anthony Keeley, Dominique Soldati

❮ Previous
Next ❯

Citations

Jun 28, 2013·Malaria Journal·Sreelakshmi K SreenivasamurthyT S Keshava Prasad
Dec 3, 2015·Parasites & Vectors·Michael B Wells, Deborah J Andrew
Mar 26, 2016·Frontiers in Microbiology·Parik KakaniSanjeev Kumar
Apr 23, 2015·Integrative and Comparative Biology·Julián F Hillyer
Sep 25, 2014·Frontiers in Plant Science·Miguel Moreno-GarcíaHumberto Lanz-Mendoza
Apr 6, 2017·Scientific Reports·Michael B WellsDeborah J Andrew
May 7, 2019·Briefings in Functional Genomics·José L Ruiz, Elena Gómez-Díaz
Jan 4, 2019·Malaria Journal·David A O'BrochtaPeter F Billingsley
Oct 31, 2020·Biology of the Cell·Melika HajkazemianS Noushin Emami
Oct 12, 2018·Microbiology Spectrum·Maureen LarochePhilippe Parola

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

© 2021 Meta ULC. All rights reserved