PMID: 2249590May 1, 1990

Invasion of mouse lung adenocarcinoma (LA795) cell aggregates transplanted into auricle of syngenic T739 mice

Zhonghua zhong liu za zhi [Chinese journal of oncology]
S D Xu


To evaluate invasion quantitatively and qualitatively in vivo, tumor cell aggregate invasion model was established. Mouse lung adenocarcinoma cell line (LA795) cells were allowed to form tumor cell aggregates after 3 days in a gyratory shaker culture system. LA795 cell aggregates, 0.3 mm in diameter, were transplanted subcutaneously to the auricles of syngenic T739 mice, which were then sacrificed at different intervals. Tumorigenicity was 100%. The process of invasion was divided into 5 stages: latent, proliferation, early invasion, mid and late invasion stages. In the mid and late invasion stages, cartilage and its capsule were invaded and progressively destroyed by tumor cells. Cartilage could be used as a criterion of judging invasion. Metastasis into the submaxillary lymph nodes (2/5) was found in the late invasion stage. The tumor cell aggregate invasion model is very useful in studying the invasion in vivo.

Related Concepts

Carcinoma, Cribriform
External Ear
Malignant Neoplasm of Lung
Lymphatic Metastasis
Mice, Inbred Strains
Neoplasm Invasiveness
Neoplasm Transplantation
Isogenic Transplantation
Tumor Cells, Cultured

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