Invasion of Porphyromonas gingivalis strains into vascular cells and tissue

Journal of Oral Microbiology
Ingar Olsen, Ann Progulske-Fox

Abstract

Porphyromonas gingivalis is considered a major pathogen in adult periodontitis and is also associated with multiple systemic diseases, for example, cardiovascular diseases. One of its most important virulence factors is invasion of host cells. The invasion process includes attachment, entry/internalization, trafficking, persistence, and exit. The present review discusses these processes related to P. gingivalis in cardiovascular cells and tissue. Although most P. gingivalis strains invade, the invasion capacity of strains and the mechanisms of invasion including intracellular trafficking among them differ. This is consistent with the fact that there are significant differences in the pathogenicity of P. gingivalis strains. P. gingivalis invasion mechanisms are also dependent on types of host cells. Although much is known about the invasion process of P. gingivalis, we still have little knowledge of its exit mechanisms. Nevertheless, it is intriguing that P. gingivalis can remain viable in human cardiovascular cells and atherosclerotic plaque and later exit and re-enter previously uninfected host cells.

References

Jan 22, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Emil V KozarovAnn Progulske-Fox
Dec 4, 2008·FEMS Immunology and Medical Microbiology·Atsushi SaitoKazuyuki Ishihara
Nov 19, 2011·Journal of Clinical Periodontology·Inmaculada TomásNikolaos Donos
May 3, 2013·Journal of Clinical Periodontology·Leticia ReyesAnn Progulske-Fox
May 3, 2013·Journal of Periodontology·Leticia ReyesAnn Progulske-Fox

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Citations

Jul 13, 2016·Mediators of Inflammation·P C Carvalho-FilhoS C Trindade
Jan 21, 2017·Anaerobe·Teresa OlczakZbigniew Ciunik
Jul 25, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shailendra P SinghSalomon Amar
May 8, 2019·International Journal of Rheumatic Diseases·Małgorzata Radwan-OczkoClaus Rasmussen
Mar 7, 2017·Frontiers in Cellular and Infection Microbiology·Tsute ChenIngar Olsen
Mar 23, 2017·Journal of Oral Microbiology·J-L C MougeotF K B Mougeot
May 17, 2019·International Journal of Environmental Research and Public Health·Giancarlo A CuadraDominic L Palazzolo
May 10, 2020·Periodontology 2000·David HerreraBjorn Klinge
Jan 24, 2019·Journal of Oral Microbiology·Ingar Olsen, Özlem Yilmaz
Sep 12, 2019·Frontiers in Aging Neuroscience·Büin AdamsEtheresia Pretorius
Aug 15, 2020·Frontiers in Cell and Developmental Biology·Qian LiXiangying Ouyang
Feb 2, 2021·Frontiers in Cardiovascular Medicine·Faraedon ZardawiJulian Yates
Jan 21, 2021·Journal of Clinical Medicine·Ruben Aquino-Martinez, Scarlette Hernández-Vigueras
Apr 4, 2021·Molecular Oral Microbiology·William A ChenDanilo S Boskovic

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Methods Mentioned

BETA
biopsies
flow cytometry

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