Invasive and non-invasive monitoring of hepatitis C virus-induced liver fibrosis: alternatives or complements?

Current Pharmaceutical Biotechnology
O Znoiko Olga, D Yuschuk Nikolai

Abstract

Chronic hepatitis C virus (HCV) infection results in the development of liver fibrosis and cirrhosis in 20 to 25% of patients. The main task of the physician when examining a patient with a verified HCV infection is to identify the activity of inflammatory and necrotic processes in the liver, as well as the stage of fibrosis, and the reversibility of detected changes. Along with other clinical and laboratory parameters, this plays a major role in forecasting the course of hepatitis, as well as determines the therapeutic approach in each specific case. Liver biopsy remains the best way to assess the severity of chronic hepatitis C. The risk of developing cirrhosis depends on the stage (degree of fibrosis) and the grade (degree of inflammation and necrosis) observed in the initial liver biopsy. Non-invasive diagnostic approaches attempt to evaluate the serum markers of fibrogenesis. Biochemical markers of fibrosis scoring include thrombocyte counts, the prothrombin time, ratio of alaninaminotransferase (ALT) and aspartataminotransferase (AST) levels, the level of g-glutamyl transferase and the quantity of blood serum albumin. Another set of markers is based on the detection of molecular junctions that activate fibrosis, or partic...Continue Reading

Citations

Jul 2, 2009·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Gamal Shiha
Jun 21, 2011·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Mohamed M OmranAhmed A Attallah
Oct 27, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yaron Ilan
Oct 9, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·R Todd Stravitz, Yaron Ilan
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Min-De ZengXia-Qiu Zhou
Apr 13, 2006·World Journal of Gastroenterology : WJG·Pik-Yuen CheungMengsu Yang

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