Invasive aortic pulse pressure is not superior to cuff pulse pressure in cardiovascular risk prediction.

Journal of Hypertension
E LaugesenP L Poulsen

Abstract

Aortic pulse pressure (PP) represents the hemodynamic cardiac and cerebral burden more directly than cuff PP. The objective of this study was to investigate whether invasively measured aortic PP confers additional prognostic value beyond cuff PP for cardiovascular events and death. With increasing age, cuff PP progressively underestimates aortic PP. Whether the prognostic association between cuff PP and outcomes is age-dependent remains to be elucidated. Cuff PP and invasively measured aortic PP were recorded in 21 908 patients (mean age 63 years, 58% men, 14% with diabetes) with stable angina pectoris undergoing elective coronary angiography during January 2001--December 2012. Multivariate Cox models were used to assess the association with incident myocardial infarction, stroke, and death. Discrimination was assessed using Harrell's C-index. During a median follow-up period of 3.7 years (range 0.1-10.8 years), 422 strokes, 511 myocardial infarctions, and 1530 deaths occurred. Both cuff and aortic PP were associated with stroke, myocardial infarction, and death in crude analyses. However, only cuff PP remained associated with stroke (hazard ratio per 10 mmHg, 1.06 (95% confidence interval (CI) 1.01--1.12)] and myocardial infar...Continue Reading

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Citations

Apr 8, 2021·Journal of Hypertension·Luca Zanoli, Pierre Boutouyrie
May 11, 2021·Journal of Hypertension·Antonios A ArgyrisAthanase D Protogerou
May 11, 2021·Journal of Hypertension·Esben Laugesen, Per L Poulsen
Apr 8, 2021·Journal of Hypertension·Esben Laugesen, Per L Poulsen

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