Invasive aspergillosis in critically ill patients without malignancy

American Journal of Respiratory and Critical Care Medicine
Wouter MeerssemanEric Van Wijngaerden

Abstract

Using criteria designed for invasive aspergillosis (IA) in patients with cancer, we aimed to determine the impact of IA in patients without malignancy in a medical intensive care unit (ICU). In this retrospective study, 127 patients out of 1,850 admissions (6.9%) hospitalized between 2000 and 2003 had microbiological or histopathologic evidence of Aspergillus during their ICU stay. There were 89 cases (70%) without hematologic malignancy. These patients were classified as proven IA (n = 30), probable IA (n = 37), possible IA (n = 2), or colonization (n = 20). In these patients, mean SAPS II score was 52 with a predicted mortality of 48%. The observed mortality was 80% (n = 71). Mortality of the proven and the probable IA was 97 and 87%, respectively. Postmortem examination was done in 46 out of 71 patients, and 27 autopsies (59%) showed hyphael invasion with Aspergillus. Aspergillus infections occurred in five critically ill patients with proven IA who did not have any predisposing factors according to the currently available definitions. Three of these patients had Child C liver cirrhosis. IA is an emerging and devastating infectious disease in patients in the ICU without malignancy. In those patients, host criteria for probab...Continue Reading

References

Mar 1, 1970·Medicine·R C YoungV T DeVita
Jun 24, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J RelloJ Valles
Apr 9, 1999·Medicine·D L Paterson, N Singh
Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D A StevensG A Pankey
Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S AsciogluUNKNOWN Mycoses Study Group of the National Institute of Allergy and Infectious Diseases
Feb 19, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elias J AnaissieThomas J Walsh
Mar 9, 2002·Journal of Computer Assisted Tomography·Michael B GotwayW Richard Webb
Aug 9, 2002·The New England Journal of Medicine·Raoul HerbrechtUNKNOWN Invasive Fungal Infections Group of the European Organisation for Research and Treatment of Cancer and the Global Aspergillu
Aug 21, 2002·JAMA : the Journal of the American Medical Association·Djillali AnnaneEric Bellissant
Apr 8, 2003·Journal of Chemotherapy·G DimopoulosJ L Vincent
Sep 17, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David W DenningHelen Sambatakou
Oct 11, 2003·Lancet·David W Denning
Dec 5, 2003·Lancet·Michail S Lionakis, Dimitrios P Kontoyiannis
Dec 12, 2003·The New England Journal of Medicine·Annie SulahianPatricia Ribaud

❮ Previous
Next ❯

Citations

Jul 25, 2007·Intensive Care Medicine·R J TrofA B J Groeneveld
Nov 8, 2008·Intensive Care Medicine·Antoni TorresUNKNOWN European HAP working group
May 5, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K L MortensenM C Arendrup
Nov 22, 2007·Wiener medizinische Wochenschrift·Alexandra ObradovicElisabeth Presterl
Feb 28, 2006·Revista iberoamericana de micología·Catherine M RonningWilliam C Nierman
May 26, 2009·Revista iberoamericana de micología·Miguel Salavert-Lletí, Rafael Zaragoza-Crespo
Aug 22, 2007·Medical Mycology·Britt Van MeenselKatrien Lagrou
May 16, 2009·Medical Mycology·Georg MaschmeyerJohn Perfect
Aug 4, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A CornilletJ-P Gangneux
Jan 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Koenraad H Vandewoude, Dirk Vogelaers
Jun 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Wouter MeerssemanEric Van Wijngaerden
Jan 5, 2011·The Journal of Antimicrobial Chemotherapy·Johan MaertensOscar Marchetti
Nov 7, 2012·The Journal of Antimicrobial Chemotherapy·Seyedmojtaba SeyedmousaviJohan W Mouton
Jan 1, 2013·Journal of Surgical Case Reports·Jennifer H FieberWalter E Longo
Apr 9, 2005·Current Opinion in Pulmonary Medicine·Fernanda Silveira, David L Paterson
Jun 30, 2005·Current Opinion in Infectious Diseases·Jacques BilleThierry Calandra
Mar 4, 2006·Current Opinion in Infectious Diseases·Ana RañóAntoni Torres
Jan 20, 2007·Southern Medical Journal·Stijn I Blot, Koenraad H Vandewoude
Nov 4, 2008·Current Opinion in Infectious Diseases·Elliott Geoffrey PlayfordThierry Calandra
Mar 12, 2009·Current Opinion in Infectious Diseases·Johan MaertensPascal Van Bleyenbergh
Oct 12, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Zhichu DaiWancheng Tong
Aug 2, 2012·Antimicrobial Agents and Chemotherapy·Stefan WeilerRomuald Bellmann
Apr 11, 2008·Clinical Microbiology Reviews·L Beth Gadkowski, Jason E Stout
Feb 9, 2007·Journal of Clinical Microbiology·Ignace Surmont, Willem Stockman
Sep 22, 2007·American Journal of Respiratory and Critical Care Medicine·Wouter MeerssemanEric Van Wijngaerden
Apr 21, 2012·American Journal of Respiratory and Critical Care Medicine·Stijn I BlotUNKNOWN AspICU Study Investigators
Jul 4, 2012·American Journal of Respiratory and Critical Care Medicine·Elie Azoulay, Bekele Afessa
Sep 10, 2004·American Journal of Respiratory and Critical Care Medicine·David W Denning
Mar 9, 2005·American Journal of Respiratory and Critical Care Medicine·Derek AngusEdward Abraham
Feb 3, 2007·BMC Gastroenterology·Hélène ProdanovicThomas Similowski
Jan 25, 2013·BMC Infectious Diseases·John W BaddleyMiriam Tarallo
Apr 14, 2011·European Journal of Medical Research·A Mayr, Cornelia Lass-Flörl
Oct 19, 2013·Multidisciplinary Respiratory Medicine·Nuri TutarRamazan Demir
Jul 1, 2005·Critical Care : the Official Journal of the Critical Care Forum·José Garnacho-MonteroFernando Barcenilla
Mar 2, 2006·Critical Care : the Official Journal of the Critical Care Forum·Koenraad H VandewoudeDirk Vogelaers
Apr 6, 2006·Critical Care : the Official Journal of the Critical Care Forum·Jose Garnacho-Montero, Rosario Amaya-Villar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Related Papers

The New England Journal of Medicine
François BlotGérard M Nitenberg
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
J RelloJ Valles
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
S AsciogluMycoses Study Group of the National Institute of Allergy and Infectious Diseases
© 2022 Meta ULC. All rights reserved